Translational Research Initiative

转化研究计划

• 批准号: MC_PC_18040
• 负责人: Ferenc Mueller
• 金额: $ 80.27万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_18040
• 关键词: Translational; Research; Initiative

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Use of In Vitro Dynamic Colon Model (DCM) to Inform a Physiologically Based Biopharmaceutic Model (PBBM) to Predict the In Vivo Performance of a Modified-Release Formulation of Theophylline.

使用体外动态结肠模型（DCM）来告知基于生理的生物制药模型（PBBM），以预测茶碱的改性释放配方的体内性能。

• DOI: 10.3390/pharmaceutics15030882
• 发表时间: 2023-03-09
• 期刊: Pharmaceutics
• 影响因子: 5.4
• 作者: Stamatopoulos K;O'Farrell C;Simmons MJH;Batchelor HK;Mistry N
• 通讯作者: Mistry N

Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model.

• DOI: 10.3390/pharmaceutics14010184
• 发表时间: 2022-01-13
• 期刊: Pharmaceutics
• 影响因子: 5.4
• 作者: Schütt M;O'Farrell C;Stamatopoulos K;Hoad CL;Marciani L;Sulaiman S;Simmons MJH;Batchelor HK;Alexiadis A
• 通讯作者: Alexiadis A

The Effect of Biorelevant Hydrodynamic Conditions on Drug Dissolution from Extended-Release Tablets in the Dynamic Colon Model.

• DOI: 10.3390/pharmaceutics14102193
• 发表时间: 2022-10-14
• 期刊: PHARMACEUTICS
• 影响因子: 5.4
• 作者: O'Farrell, Connor;Simmons, Mark J. H.;Batchelor, Hannah K.;Stamatopoulos, Konstantinos
• 通讯作者: Stamatopoulos, Konstantinos

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment.

• DOI: 10.1182/bloodadvances.2022008272
• 发表时间: 2023-05-09
• 期刊: BLOOD ADVANCES
• 影响因子: 7.5
• 作者: Panetti, Silvia;McJannett, Nicola;Fultang, Livingstone;Booth, Sarah;Gneo, Luciana;Scarpa, Ugo;Smith, Charles;Vardon, Ashley;Vettore, Lisa;Whalley, Celina;Pan, Yi;Varnai, Csilla;Endou, Hitoshi;Barlow, Jonathan;Tennant, Daniel;Beggs, Andrew;Mussai, Francis;De Santo, Carmela
• 通讯作者: De Santo, Carmela

Development of a digital twin of a tablet that mimics a real solid dosage form: Differences in the dissolution profile in conventional mini-USP II and a biorelevant colon model

• DOI: 10.1016/j.ejps.2022.106310
• 发表时间: 2022-10-21
• 期刊: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
• 影响因子: 4.6
• 作者: Schuett, M.;Stamatopoulos, K.;Alexiadis, A.
• 通讯作者: Alexiadis, A.