Northern New England Clinical and Translational Research Network - N3C Initiative

新英格兰北部临床和转化研究网络 - N3C Initiative

• 批准号: 10887984
• 负责人: CLIFFORD JAMES ROSEN
• 金额: $ 34.83万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-03 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10887984
• 关键词: 2019-nCoV; Acceleration; Address; Administrative Supplement; Area; Artificial Intelligence; Big Data; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 patient; COVID-19 treatment; Cardiovascular Diseases; Clinical Data; Clinical Research; Collaborations; Communities; Community Health; Contracts; Coupled; Cultural Diversity; Data; Databases; Dedications; Deposition; Development; Diabetes Mellitus; Disease; Education; Education and Outreach; Educational Activities; Food; Funding; Goals; Health; Immigrant; Infrastructure; Institution; Leadership; Link; Machine Learning; Maine; Malignant Neoplasms; Manuscripts; Minority; National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Native Americans; New England; New Hampshire; Obesity; Patients; Population; Refugees; Registries; Reporting; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Rural; Rural Health; Sampling; Science; Scientist; Secure; Substance Use Disorder; System; Techniques; Training and Education; Translational Research; Tribes; Underserved Population; United States National Institutes of Health; Universities; Variant; Vermont; Viral; Work; cloud based; cohort; community based research; computer infrastructure; data infrastructure; data registry; data warehouse; effective therapy; experience; health disparity; human old age (65+); improved; innovation; interest; investigator training; member; operation; outcome disparities; pandemic disease; practice-based research network; primary care practice; rural dwellers; rurality

ABSTRACT The National Covid Cohort Collaborative (N3C), sponsored by the National Center for Advancing Translational Sciences (NCATS) and the National Center for Data to Health (Cd2H) have created a centralized national database on a cloud-based analytic platform for scientists to use to study COVID-19, identify potential treatments, and report on outcomes and health disparities. It is a partnership among more than 80 institutions that is funded by the National Institutes of Health. Collaborators have contributed data so far on nearly 8 million COVID-19 positive patients, as well as several million control patients. The collaborators use the clinical data on these patients to answer critical research questions to address the pandemic and accelerate development of effective treatments. The Northern New England Clinical and Translational Research Network has actively participated in N3C for over 3 years and is submitting this administrative supplement to allow for our continued participation for another year. This application details our past accomplishments and describes our planned work for the coming year.

摘要 国家新冠肺炎队列协作（N3 C），由国家推进翻译中心赞助 科学（NCATS）和国家健康数据中心（Cd 2 H）已经创建了一个集中的国家 基于云的分析平台上的数据库，供科学家用于研究COVID-19， 治疗，并报告结果和健康差距。它是80多个机构之间的合作伙伴关系 这是由美国国立卫生研究院资助的。到目前为止，合作者已经提供了近800万个数据， COVID-19阳性患者，以及数百万对照患者。合作者使用临床数据 这些患者回答关键的研究问题，以应对大流行并加速发展 有效的治疗方法。北方新英格兰临床和转化研究网络积极 参加N3 C超过3年，并提交此行政补充，以允许我们继续 再参加一年。此应用程序详细介绍了我们过去的成就，并描述了我们的计划 为来年工作。

项目成果

Increasing intraoperative hydromorphone does not decrease postoperative pain: a retrospective observational study.

术中增加氢吗啡酮并不能减轻术后疼痛：一项回顾性观察研究。

• DOI: 10.1016/j.bja.2020.11.026
• 发表时间: 2021
• 期刊: British journal of anaesthesia
• 影响因子: 9.8
• 作者: Curry,CraigS;Craig,WendyY;Richard,JanelleM;Ward,DenhamS
• 通讯作者: Ward,DenhamS

Liposomal bupivacaine in transversus abdominis plane blocks for lower abdominal surgery.

脂质体布比卡因在腹横肌平面块中用于下腹部手术。

• DOI: 10.1111/papr.13347
• 发表时间: 2024
• 期刊: Pain practice : the official journal of World Institute of Pain
• 作者: Osuchukwu,Obiyo;Gagnon,James;Richard,Janelle;Craig,Wendy;Quaye,Aurora
• 通讯作者: Quaye,Aurora

Decreased expression of ErbB2 on left ventricular epicardial cells in patients with diabetes mellitus.

糖尿病患者左心室心外膜细胞上ERBB2表达的降低。

• DOI: 10.1016/j.cellsig.2022.110360
• 发表时间: 2022-08
• 期刊: CELLULAR SIGNALLING
• 影响因子: 4.8
• 作者: De Kay, Joanne T.;Carver, Joshua;Shevenell, Bailey;Kosta, Angela M.;Tsibulnikov, Sergey;Certo, Emily;Sawyer, Douglas B.;Ryzhov, Sergey;Robich, Michael P.
• 通讯作者: Robich, Michael P.

Harm Reduction Services to Prevent and Treat Infectious Diseases in People Who Use Drugs.

• DOI: 10.1016/j.idc.2020.06.013
• 发表时间: 2020-09
• 期刊: Infectious disease clinics of North America
• 影响因子: 4.4
• 作者: Thakarar K;Nenninger K;Agmas W
• 通讯作者: Agmas W

The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis.

• DOI: 10.1002/jcp.25976
• 发表时间: 2018-03
• 期刊: Journal of cellular physiology
• 影响因子: 5.6
• 作者: Fairfield H;Falank C;Harris E;Demambro V;McDonald M;Pettitt JA;Mohanty ST;Croucher P;Kramer I;Kneissel M;Rosen CJ;Reagan MR
• 通讯作者: Reagan MR