Translational Research Capacity Building Initiative to Address Cardiovascular Diseases in Nepal

尼泊尔解决心血管疾病的转化研究能力建设倡议

• 批准号: 9297422
• 负责人: Rajendra Koju
• 金额: $ 14.9万
• 依托单位: DHULIKHEL HOSPITAL KATHMANDU UNIVERSITY HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9297422
• 关键词: Address; Advisory Committees; Behavior Therapy; Cardiovascular Diseases; Caring; Cessation of life; China; Clinical; Communities; Data; Data Analyses; Data Sources; Developing Countries; Disease Management; Education; Environmental Risk Factor; Epidemiology; Ethnic Origin; Evidence based intervention; Faculty; Foundations; Gender; Goals; Government; Health; Health system; Healthcare Systems; Hospitals; Human Resources; Hypertension; Income; India; Individual; Institution; International; Intervention; Lead; Low income; Methods; Modeling; Myocardial Ischemia; Nepal; Outcome; Pathway interactions; Patients; Policies; Population; Prevention; Prevention Measures; Preventive Intervention; Process; Public Health; Publishing; Registries; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Stroke; Structure; Surveys; System; The Sun; Training; Training Programs; Translational Research; Universities; University Hospitals; Washington; Wisconsin; Work; base; cardiovascular disorder epidemiology; cardiovascular disorder prevention; cardiovascular disorder risk; cost effective; evidence base; health care delivery; implementation research; low and middle-income countries; low income country; multidisciplinary; premature; prevent; scale up; social; uptake

PROJECT SUMMARY/ABSTRACT Translational Research Capacity Building Initiative to address Cardiovascular Diseases in Nepal Cardiovascular diseases (CVDs) are the leading causes of premature death in the world with more than 80% of all CVD-related deaths occurring in low-and middle-income countries. In Nepal, CVD and their risk factors have increased alarmingly over the past decades. Although there are proven measures for prevention and appropriate management of CVD, the challenges of implementing known interventions are severely limited by gaps in: a) epidemiological understanding of CVD and its risk factors; b) national level policies and strategies to address them; c) health systems infrastructure to provide education and treatment; d) community and patient-level support at the local level; and e) human resources to lead and implement agendas when they are developed. To address these gaps, this proposed project plans to build national capacity in Nepal to lead transnational research in cardiovascular disease (CVD) by creating and training a multi-sectorial, multi- disciplinary team; building partnership with the US and regional institutions; systematically assessing national needs; and developing an actionable translational research plan. Specific aims are to: 1) Create a multi- sectorial, multidisciplinary collaborative team to lead the translational research capacity building initiative to prevent and manage CVD in Nepal; 2) Assess national level infrastructure and capacity to implement evidence based CVD prevention and management interventions and its risk factors in Nepal; 3) Identify and prioritize health issues for cardiovascular disease in Nepal; 4) Prepare a comprehensive actionable translational research plan for management of CVD in Nepal. We will consolidate existing partnerships with US Universities (University of Washington, University of Wisconsin, Faculties from Harvard University) and build new partnerships with regional institutions (Public Health Foundation of India, Sun-Yat-Sen University in China) to support these efforts. We will apply mixed methods (qualitative and quantitative) to assess the existing capacity, needs, opportunities and challenges among the governmental and non-governmental sectors to implement evidence-based interventions for prevention and management of CVD. We will conduct secondary data analysis on epidemiology of CVD by using data sources from national surveys, hospital-based data and published and unpublished research to identify the epidemiology of CVD in the context of region, gender, ethnicity, and income groups of Nepal. We will initiate efforts to ascertain MI and stroke via a pilot registry. By the end of the project, we will have developed a critical mass of human resources in Nepal, collaborating with national and international partners to conduct translational research in CVD. We will have defined clearly identified prioritized needs and a well-defined implementation research plan to address one or more major CVD risk factors and outcomes. The team will thus form a ‘Center of Excellence for Translational Research in Cardiovascular Diseases’, which will also serve as a model for other resource-constrained settings around the world.

项目总结/摘要 尼泊尔应对心血管疾病转化研究能力建设倡议 心血管疾病（CVD）是世界上过早死亡的主要原因， 低收入和中等收入国家发生的所有心血管疾病相关死亡。在尼泊尔，CVD及其危险因素 在过去的几十年里有惊人的增长。虽然有行之有效的预防措施， 适当的CVD管理，实施已知干预措施的挑战受到严重限制， 在以下方面存在差距：a）对心血管疾病及其风险因素的流行病学理解; B）国家一级的政策和战略 （c）提供教育和治疗的卫生系统基础设施;（d）社区和 在地方一级提供病人一级的支持; e）人力资源，在需要时领导和执行议程。 开发为了弥补这些差距，本拟议项目计划在尼泊尔建设国家能力， 心血管疾病（CVD）的跨国研究，通过创建和培训一个多部门，多 学科团队;与美国和区域机构建立伙伴关系;系统地评估国家 需要;并制定一个可行的转化研究计划。具体目标是：1）创建一个多- 部门，多学科合作团队，领导转化研究能力建设倡议， 在尼泊尔预防和管理心血管疾病; 2）评估国家一级的基础设施和能力，以实施证据 基于CVD预防和管理干预措施及其在尼泊尔的风险因素; 3）确定并优先考虑 尼泊尔心血管疾病的健康问题; 4）准备一个全面的可操作的翻译 尼泊尔心血管疾病管理研究计划。我们将巩固与美国大学的现有合作伙伴关系 （华盛顿大学、威斯康星州大学、哈佛大学的院系）并建立新的 与区域机构（印度公共卫生基金会、中国中山大学）建立伙伴关系， 支持这些努力。我们将采用混合方法（定性和定量）来评估现有的 政府和非政府部门的能力、需要、机会和挑战， 实施循证干预措施，预防和管理心血管疾病。我们将进行第二次 通过使用国家调查数据源、基于医院的数据和 已发表和未发表的研究，以确定CVD在地区，性别， 尼泊尔的种族和收入群体。我们将通过试点登记研究确定MI和卒中。通过 在项目结束时，我们将在尼泊尔开发出一批关键的人力资源， 国家和国际合作伙伴在CVD进行转化研究。我们将清楚地定义 确定了优先需求，并制定了明确的实施研究计划，以解决一个或多个主要问题 CVD危险因素和结果。因此，该团队将成立一个“卓越的翻译研究中心， 心血管疾病”，这也将成为世界各地其他资源受限环境的典范 世界