Tropical Infectious Disease Consortium: Expanding and Accelerating Product Development

热带传染病联盟：扩大并加速产品开发

• 批准号: MC_PC_18055
• 负责人: Stephen Ward
• 金额: $ 68.81万
• 依托单位: Liverpool School of Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_18055
• 关键词: Tropical; Infectious; Disease; Consortium; Expanding

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

GTR目前尚未用于所有资助研究的摘要。这通常是因为提交提案时不需要摘要，但可能是因为它包含了敏感信息，例如个人详细信息。

项目成果

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite.

两种小分子毒素抑制剂的治疗组合提供了针对蝰蛇咬伤的广泛临床前疗效。

• DOI: 10.1038/s41467-020-19981-6
• 发表时间: 2020-12-15
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Albulescu LO;Xie C;Ainsworth S;Alsolaiss J;Crittenden E;Dawson CA;Softley R;Bartlett KE;Harrison RA;Kool J;Casewell NR
• 通讯作者: Casewell NR

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

• DOI: 10.1101/2022.05.20.492855
• 发表时间: 2022-05-20
• 期刊: bioRxiv
• 作者: Hall, S. R.;Rasmussen, S. A.;Casewell, N. R.
• 通讯作者: Casewell, N. R.

Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform.

• DOI: 10.3389/fphar.2023.1331224
• 发表时间: 2023
• 期刊: FRONTIERS IN PHARMACOLOGY
• 影响因子: 5.6
• 作者: Albulescu, Laura-Oana;Westhorpe, Adam;Clare, Rachel H.;Woodley, Christopher M.;James, Nivya;Kool, Jeroen;Berry, Neil G.;O'Neill, Paul M.;Casewell, Nicholas R.
• 通讯作者: Casewell, Nicholas R.

Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti- Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis

AWZ1066S 的制造工艺从发现到公斤级的转变：用于短期治疗丝虫病的高度特异性抗沃尔巴克氏体候选药物

• DOI: 10.1021/acs.oprd.2c00167
• 发表时间: 2023
• 期刊: Organic Process Research & Development
• 影响因子: 3.4
• 作者: Hong W

Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis

• DOI: 10.3389/fmicb.2024.1346068
• 发表时间: 2024-02-01
• 期刊: FRONTIERS IN MICROBIOLOGY
• 影响因子: 5.2
• 作者: Hegde，Shrilakshmi;Marriott，Amy E.;Turner，Joseph D.
• 通讯作者: Turner，Joseph D.