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Tropical Infectious Disease Consortium: Expanding and Accelerating Product Development

Tropical Infectious Disease Consortium: Expanding and Accelerating Product Development
热带传染病联盟：扩大并加速产品开发
批准号：
MC_PC_18055
负责人：
Stephen Ward
金额：
$68.81万
依托单位：
Liverpool School of Tropical Medicine
依托单位国家：
英国
项目类别：
Intramural
财政年份：
2019
资助国家：
英国
项目状态：
已结题
起止时间：
2019 至 --
来源：
https://gtr.ukri.org/projects?ref=MC_PC_18055
关键词：
TropicalInfectiousDiseaseConsortiumExpanding

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中文摘要
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英文摘要
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
期刊论文(10)
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会议论文
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite.
两种小分子毒素抑制剂的治疗组合提供了针对蝰蛇咬伤的广泛临床前疗效。
DOI： 10.1038/s41467-020-19981-6
发表时间： 2020-12-15
期刊： Nature communications
影响因子： 16.6
作者： [Albulescu LO, Xie C, Ainsworth S, Alsolaiss J, Crittenden E, Dawson CA, Softley R, Bartlett KE, Harrison RA, Kool J, Casewell NR]
通讯作者： Casewell NR
Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform.
DOI： 10.3389/fphar.2023.1331224
发表时间： 2023
期刊： FRONTIERS IN PHARMACOLOGY
影响因子： 5.6
作者： [Albulescu, Laura-Oana, Westhorpe, Adam, Clare, Rachel H., Woodley, Christopher M., James, Nivya, Kool, Jeroen, Berry, Neil G., O'Neill, Paul M., Casewell, Nicholas R.]
通讯作者： Casewell, Nicholas R.
Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti- Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis
AWZ1066S 的制造工艺从发现到公斤级的转变：用于短期治疗丝虫病的高度特异性抗沃尔巴克氏体候选药物
DOI： 10.1021/acs.oprd.2c00167
发表时间： 2023
期刊： Organic Process Research & Development
影响因子： 3.4
作者： [Hong W]
通讯作者： Hong W
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis
DOI： 10.3389/fmicb.2024.1346068
发表时间： 2024-02-01
期刊： FRONTIERS IN MICROBIOLOGY
影响因子： 5.2
作者： [Hegde，Shrilakshmi, Marriott，Amy E., Turner，Joseph D.]
通讯作者： Turner，Joseph D.
Tropical Infectious Disease Consortium (TIDC) – Confidence in Concept 2019
MICA: Pre-Clinical Development of a Small Molecule anti-Wolbachia Candidate Macrofilaricide Drug
  • 批准号：
    MR/R025401/1
  • 项目类别：
    Research Grant
  • 资助金额：
    $189.94万
  • 财政年份：
    2018
  • 负责人：
    Stephen Ward
  • 依托单位：
    Liverpool School of Tropical Medicine
Tropical Infectious Disease Consortium: Expanding and Accelerating ProductDevelopment
Tropical Infectious Disease Consortium: Expanding and Accelerating Product Development (LSTM P2D 2017)
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