TROPICAL INFECTIOUS DISEASE TRAINING GRANT

热带传染病培训补助金

• 批准号: 7942524
• 负责人: Edgar M Carvalho
• 金额: $ 3.14万
• 依托单位: FEDERAL UNIVERSITY OF BAHIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-12 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942524
• 关键词: Address; Area; Brazil; Clinical; Clinical Immunology; Clinical Trials; Collaborations; Communicable Diseases; Country; Disease; Disease Outcome; Ethics; Genetic; Grant; Hereditary Disease; Human T-lymphotropic virus 1; Immune response; Immunology; Immunotherapy; Institution; Iowa; Leishmaniasis; Measures; Mentors; Molecular; Pathogenesis; Pennsylvania; Physicians; Research; Research Personnel; Research Support; Resources; Schistosomiasis; Services; Specific qualifier value; Training; Training Programs; Tropical Disease; United States National Institutes of Health; Universities; clinical epidemiology; graduate student; pathogen; post-doctoral training; programs; response

DESCRIPTION (provided by applicant): The Immunology Service of the Federal University of Bahia has ongoing research programs on endemic tropical diseases (leishmaniasis, schistosomiasis, HTLV-1) in collaboration with US and other Brazilian institutions aimed at: 1) Characterizing the immune response to these pathogens, 2) Correlating immunological response with clinical manifestations of these diseases, 3) Studying genetic contributions to disease outcome, 4) Identifying new forms of therapy and control measures, and 5) Identifying pathogen components that interfere in disease outcome. The Federal University of Bahia has taken advantage of its collaboration with Cornell University in the past, through training of young investigators in Fogarty-sponsored Training Programs. Although the Immunology Service receives support for research (including a TMRC, NIH grant), there is no specific support for addressing training needs required to implement these projects. The present proposal will use needs identified in the studies of leishmaniasis to address the following specific aims: 1) To create training opportunities in areas such as genetics, disease pathogenesis, clinical investigation and ethics, 2) To disseminate training to other investigators from Bahia and other universities of Brazil. To address the first aim this program emphasizes collaboration with foreign universities (Cornell University, University of Iowa, Johns Hopkins, University of Pennsylvania, Cambridge University) for longterm training of post-doctoral fellows (total of 5) and short-term advanced training for young and senior investigators (total of 5) to address the specific needs in expertise within the specified areas. The second aim will be addressed by using the in-country expertise and resources and the advanced trained mentors to provide training for graduate, post-graduate students, young investigators, physicians and technicians in areas such as basic and clinical immunology, immunotherapy, molecular and clinical epidemiology, as well as in the new areas specified above after the training of the Brazilian mentors.

描述（申请人提供）：巴伊亚联邦大学免疫学服务部正在进行关于地方性热带病的研究项目（利什曼病、血吸虫病、HTLV-1），与美国和其他巴西机构合作，旨在：1）表征对这些病原体的免疫应答，2）将免疫应答与这些疾病的临床表现相关联，3）研究遗传对疾病结果的贡献，4）确定新的治疗和控制措施，5）确定干扰疾病结果的病原体成分。巴伊亚的联邦大学过去曾利用与康奈尔大学的合作，通过福格蒂赞助的培训计划培训年轻的调查人员。尽管免疫学服务得到了研究支持（包括TMRC，NIH赠款），但没有具体的支持来满足实施这些项目所需的培训需求。本提案将利用利什曼病研究中确定的需求，以实现以下具体目标：（1）在遗传学、疾病发病机理、临床调查和伦理学等领域创造培训机会，（2）向来自巴伊亚和巴西其他大学的其他调查人员传播培训。为了实现第一个目标，该计划强调与外国大学（康奈尔大学，爱荷华州大学，约翰霍普金斯，宾夕法尼亚大学，剑桥大学）合作，对博士后研究员进行长期培训（共5名），并对年轻和高级研究人员进行短期高级培训（共5名），以满足特定领域的专业知识的具体需求。为实现第二个目标，将利用国内的专门知识和资源以及受过高级培训的导师，在基础和临床免疫学、免疫疗法、分子和临床流行病学等领域以及在巴西导师培训后在上述新领域为本科生、研究生、年轻调查人员、医生和技术人员提供培训。

项目成果

Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis.

感染性皮炎与人类 T 淋巴细胞病毒 1 型相关脊髓病/热带痉挛性截瘫具有相似的免疫学特征。

• DOI: 10.1111/j.1365-2249.2008.03869.x
• 发表时间: 2009
• 期刊: Clinical and experimental immunology
• 影响因子: 4.6
• 作者: Nascimento,MCF;Primo,J;Bittencourt,A;Siqueira,I;deFátimaOliveira,M;Meyer,R;Schriefer,A;Santos,SB;Carvalho,EM
• 通讯作者: Carvalho,EM

High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1.

在与 HTLV-1 相关的感染性皮炎患者中也检测到高 HTLV-1 前病毒载量，这是 HTLV-1 相关脊髓病/热带痉挛性截瘫的标志物。

• DOI: 10.1590/s0100-879x2009005000008
• 发表时间: 2009
• 期刊: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
• 作者: Primo,J;Siqueira,I;Nascimento,MCF;Oliveira,MF;Farre,L;Carvalho,EM;Bittencourt,AL
• 通讯作者: Bittencourt,AL

Antihelminthic therapy and antimony in cutaneous leishmaniasis: a randomized, double-blind, placebo-controlled trial in patients co-infected with helminths and Leishmania braziliensis.

皮肤利什曼病的抗蠕虫疗法和锑：一项针对同时感染蠕虫和巴西利什曼原虫的患者进行的随机、双盲、安慰剂对照试验。

• DOI: 10.4269/ajtmh.2011.10-0423
• 发表时间: 2011
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Newlove,Tracey;Guimarães,LuizH;Morgan,DanielJ;Alcântara,Leda;Glesby,MarshallJ;Carvalho,EdgarM;Machado,PauloR
• 通讯作者: Machado,PauloR

Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1.

HTLV-1 携带者和 HTLV-1 相关脊髓病患者 T 细胞反应的调节。

• DOI: 10.1159/000097259
• 发表时间: 2006
• 期刊: Neuroimmunomodulation
• 影响因子: 2.4
• 作者: Santos,SilvaneB;Porto,AureliaF;Muniz,AndreLuiz;Luna,Tania;Nascimento,MarciaC;Guerreiro,JaquelineB;Oliveira-Filho,Jamary;Morgan,DanielJ;Carvalho,EdgarM
• 通讯作者: Carvalho,EdgarM

Geographic clustering of leishmaniasis in northeastern Brazil.

巴西东北部利什曼病的地理聚集。

• DOI: 10.3201/eid1506.080406
• 发表时间: 2009
• 期刊: Emerging infectious diseases
• 影响因子: 11.8
• 作者: Schriefer,Albert;Guimaraes,LuizH;Machado,PauloRL;Lessa,Marcus;Lessa,HelioA;Lago,Ednaldo;Ritt,Guilherme;Goes-Neto,Aristoteles;Schriefer,AnaLF;Riley,LeeW;Carvalho,EdgarM
• 通讯作者: Carvalho,EdgarM