Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life.
Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life.
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DOI：
10.1183/13993003.04015-2020
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Parravicini P
中科院分区：
文献类型：
--
作者：
Anastasio F;Barbuto S;Scarnecchia E;Cosma P;Fugagnoli A;Rossi G;Parravicini M;Parravicini P
冠状病毒病2019(新冠肺炎)已在全球蔓延，对医疗体系产生巨大影响。本研究的目的是评估新冠肺炎对呼吸功能的中期临床影响。在严重急性呼吸综合征冠状病毒 确诊后4个月对379例患者进行评估。根据新冠肺炎期间肺炎的存在情况，患者被分为两组。分析患者的临床情况、生活质量、症状、6min步行试验、肺功能测定及肺一氧化碳弥散量。将数据与新冠肺炎期间的临床演变(急性呼吸窘迫综合征的发生、是否需要有创机械通气、部分血氧饱和度(SpO2)/吸入氧分数(FiO2)和肺炎严重程度指数(PSI))进行比较。在中位数135 天后，379名患者中有260名(68.6%)至少出现一种症状。新冠肺炎期间发生肺炎的患者与非肺炎患者相比，静息SpO2(p<；0.001)、6min步行SpO2(p<；0.001)、总肺活量(p<；0.001)、0.1min后气道闭塞压(p0.1)、P0.1/最大吸气压比(p=0.005)、Borg分类比(p=0.006)和改良医学研究委员会气喘量表(p=0.003)均显著降低。SARS-CoV-2肺炎期间SpO2/FiO2比值和PSI与静息SpO2(p<；0.001)和6min步行试验SpO2(p<；0.001)、残气量(p<；0.001)、总肺活量(p<；0.001和p=0.003)、用力肺活量(p=0.004和p=0.03)的中期变化直接相关。新冠肺炎期间的肺损伤与急性感染后4 月的肺功能下降有关。新冠肺炎严重肺部受累中长期可降低呼吸性能。建议新冠肺炎幸存者对出现严重临床和放射学症状的患者进行呼吸康复。Https://bit.ly/3jCxN0s
Coronavirus disease 2019 (COVID-19) has spread worldwide, having a dramatic impact on healthcare systems. The aim of this study is to evaluate mid-term clinical impact of COVID-19 on respiratory function. 379 patients were evaluated 4 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis. Patients were divided in two groups based on the presence of pneumonia during COVID-19. Clinical conditions, quality of life, symptomatology, 6-min walk test, pulmonary function test with spirometry and diffusing capacity of the lung for carbon monoxide were analysed. Data were compared to clinical evolution during COVID-19 (development of acute respiratory distress syndrome, need of invasive mechanical ventilation, partial oxygen saturation (SpO2)/inspiratory oxygen fraction (FIO2) ratio and pneumonia severity index (PSI)). After a median 135 days, 260 (68.6%) out of 379 patients referred at least one symptom. Patients who developed pneumonia during COVID-19 showed lower SpO2 at rest (p<0.001), SpO2 during 6-min walk test (p<0.001), total lung capacity (p<0.001), airway occlusion pressure after 0.1 s (P0.1) (p=0.02), P0.1/maximal inspiratory pressure ratio (p=0.005) and higher Borg category-ratio scale (p=0.006) and modified Medical Research Council breathlessness scale (p=0.003), compared to patients without pneumonia. SpO2/FIO2 ratio and PSI during SARS-CoV-2 pneumonia were directly associated with mid-term alteration of SpO2 at rest (p<0.001) and during 6-min walk test (p<0.001), residual volume (p<0.001), total lung capacity (p<0.001 and p=0.003, respectively) and forced vital capacity (p=0.004 and p=0.03, respectively). Lung damage during COVID-19 correlates to the reduction of pulmonary function 4 months after acute infection. COVID-19 severe lung involvement can reduce respiratory performance in the medium- to long-term. Respiratory rehabilitation is recommended in COVID-19 survivors showing severe clinical and radiological signs of disease. https://bit.ly/3jCxN0s
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DOI：
10.1183/09031936.00080312
发表时间：
2012-12
期刊：
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影响因子：
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发表时间：
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期刊：
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影响因子：
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