Determination of Disease Specific Epitopes in Rheumatic Heart Disease in Australia

澳大利亚风湿性心脏病疾病特异性表位的测定

• 批准号: nhmrc : 540419
• 负责人: Prof Madeleine Cunningham
• 金额: $ 24.99万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determination-disease-specific-disease-australia/101106
• 关键词: Determination; Disease; Specific; Epitopes; Rheumatic

Rheumatic Fever and Rheumatic Heart Disease (RF-RHD) remain a significant cause of illness in Aboriginal communities in Australia. RF-RHD is a complication which follows infection with a specific bacterium. The purpose of this study is to compare the body's response and find out the patterns of antibody and immune cell reactivity to the bacterium and body proteins in RF-RHD patients and controls. It will also enable us to study the mechanisms that initiate the disease process.

风湿热和风湿性心脏病（RF-RHD）仍然是澳大利亚土著社区的一个重要病因。RF-RHD是感染特定细菌后的并发症。本研究的目的是比较RF-RHD患者和对照组的身体反应，并找出抗体和免疫细胞对细菌和身体蛋白的反应模式。它还将使我们能够研究引发疾病过程的机制。