Exploring novel solutions of radiotherapy delivery and using biology, imaging, new fractionations and radiobiological models to improve TCP/NTCP ratio

探索放射治疗的新解决方案，并利用生物学、成像、新的分割和放射生物学模型来提高 TCP/NTCP 比率

• 批准号: MC_UU_00001/2
• 负责人: Kristoffer Petersson
• 金额: $ 317.02万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00001%2F2
• 关键词: Exploring; novel; solutions; radiotherapy; delivery

Cancers of the upper gastro-intestinal tract (oesophagus, pancreas) have a poor outcome if surgery cannot be undertaken. Radical radiotherapy combined with chemotherapy are the standard of care, however a significant number of patients have tumour recurrence in the radiotherapy field. In the past increasing radiotherapy dose caused severe toxicity. There are now several technological advances in radiotherapy that permits further individualization of treatment using either functional imaging such as MRI and PET to guide the areas that need more radiotherapy or focused radiotherapy (such as Stereotactic ablative radiotherapy) to areas of tumour that cannot be removed by surgery.The aim of the research is to further personalise the way radiotherapy is delivered using characteristics specific to an individual patient and/or tumour. Novel drugs that have been shown in laboratory to enhance radiation will be combined with the radiation to further enhance tumour kill. The ultimate impact in clinical practice would be improvement in local tumour control and reduction in toxicity caused by radiation.

如果不能进行手术，上消化道（食道、胰腺）的癌症预后较差。根治性放疗联合化疗是治疗的标准，然而，大量患者在放疗领域出现肿瘤复发。在过去，增加放射治疗剂量会引起严重的毒性。现在，放射治疗的一些技术进步允许使用功能成像（如MRI和PET）进一步个性化治疗，以指导需要更多放射治疗的区域或集中放射治疗（如立体定向消融放射治疗）该研究的目的是进一步个性化放射治疗的方式，使用个人特有的特征，患者和/或肿瘤。在实验室中已被证明可以增强辐射的新药将与辐射结合，以进一步增强肿瘤杀伤力。在临床实践中的最终影响将是改善局部肿瘤控制和减少辐射引起的毒性。

项目成果

Normal Tissue Doses During Isotoxically Dose Escalated Lung Radiation Therapy Using MR-Linacs

使用 MR-Linacs 进行等毒性剂量递增肺部放射治疗期间的正常组织剂量

• 发表时间: 2018
• 作者: Bendall L

Normal Tissue Doses during Isotoxically Dose Escalated Lung Radiotherapy using MR-Linacs

使用 MR-Linacs 等毒性剂量递增肺部放疗期间的正常组织剂量

• 发表时间: 2018
• 作者: Bendall L

PO-1121 Characterizing Dosimetric Uncertainties to Tumour Volume and Organs at Risk in Rectal Cancer

PO-1121 描述直肠癌肿瘤体积和危险器官的剂量学不确定性

• DOI: 10.1016/s0167-8140(19)31541-5
• 发表时间: 2019
• 期刊: Radiotherapy and Oncology
• 影响因子: 5.7
• 作者: Babatunde O

Impact of abdominal compression on setup error and image matching during radical abdominal radiotherapy.

腹部压缩对腹部根治性放疗期间设置误差和图像匹配的影响。

• DOI: 10.1016/j.tipsro.2019.11.003
• 发表时间: 2019
• 期刊: Technical innovations & patient support in radiation oncology
• 作者: Chu KY

EP-1626: Predicting motion of normal tissue using incomplete real-time data during lung radiotherapy

EP-1626：在肺部放射治疗期间使用不完整的实时数据预测正常组织的运动

• DOI: 10.1016/s0167-8140(17)32061-3
• 发表时间: 2017
• 期刊: Radiotherapy and Oncology
• 影响因子: 5.7
• 作者: Bendall L