Physics and Biology of FLASH Radiation

FLASH辐射的物理和生物学

• 批准号: MC_UU_00001/9
• 负责人: Kristoffer Petersson
• 金额: $ 190.21万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00001%2F9
• 关键词: Physics; Biology; FLASH; Radiation

Radiotherapy is an effective tool in the treatment of cancer. However, the full potential of radiotherapy is limited by the fact that radiation also damage healthy tissues. To avoid causing severe damage and suffering for patients receiving treatment, the radiation dose delivered must be limited. Even though, for many patients, a higher treatment dose would be necessary for curing them. In cancer treatment with FLASH radiotherapy, all the radiation dose is delivered in parts of a second, more than 1 000 times quicker than in conventional radiotherapy. This new radiotherapy technique has great potential in improving cancer treatment, as it is less toxic to healthy tissues compared to standard radiotherapy but as effective at treating tumours. However, very little is known about the biological processes behind this highly beneficial FLASH effect. We have a powerful and flexible linear accelerator available for experiments. It is capable of delivering the intense radiation fields needed for FLASH radiotherapy. By performing different cell, tissue, and mice experiments, we aim to explain the effect and to find out how to best take advantage of this treatment technique when moving towards human trials in our cancer treatment centres.

放射疗法是治疗癌症的有效手段。然而，放射治疗的全部潜力受到辐射也损害健康组织的事实的限制。为了避免对接受治疗的患者造成严重损害和痛苦，必须限制所提供的辐射剂量。尽管如此，对于许多患者来说，更高的治疗剂量将是治愈他们所必需的。在癌症治疗中，所有的辐射剂量都是在一秒钟内完成的，比传统的放射治疗快1000倍以上。这种新的放射治疗技术在改善癌症治疗方面具有巨大的潜力，因为与标准放射治疗相比，它对健康组织的毒性较小，但在治疗肿瘤方面同样有效。然而，人们对这种非常有益的闪光效应背后的生物过程知之甚少。我们有一个强大而灵活的直线加速器可用于实验。它能够提供FLASH放射治疗所需的强辐射场。通过进行不同的细胞、组织和小鼠实验，我们的目标是解释这种效果，并找出在我们的癌症治疗中心进行人体试验时如何最好地利用这种治疗技术。

项目成果

Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions.

• DOI: 10.3389/fonc.2021.686142
• 发表时间: 2021
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: Adrian G;Konradsson E;Beyer S;Wittrup A;Butterworth KT;McMahon SJ;Ghita M;Petersson K;Ceberg C
• 通讯作者: Ceberg C

Comparable Long-Term Tumor Control for Hypofractionated FLASH Versus Conventional Radiation Therapy in an Immunocompetent Rat Glioma Model.

• DOI: 10.1016/j.adro.2022.101011
• 发表时间: 2022-11
• 期刊: ADVANCES IN RADIATION ONCOLOGY
• 影响因子: 2.3
• 作者: Konradsson, Elise;Liljedahl, Emma;Gustafsson, Emma;Adrian, Gabriel;Beyer, Sarah;Ilaahi, Suhayb Ehsaan;Petersson, Kristoffer;Ceberg, Crister;Nittby Redebrandt, Henrietta
• 通讯作者: Nittby Redebrandt, Henrietta

Correction for Ion Recombination in a Built-in Monitor Chamber of a Clinical Linear Accelerator at Ultra-High Dose Rates.

• DOI: 10.1667/rade-19-00012
• 发表时间: 2020-12-01
• 期刊: Radiation research
• 影响因子: 3.4
• 作者: Konradsson E;Ceberg C;Lempart M;Blad B;Bäck S;Knöös T;Petersson K
• 通讯作者: Petersson K

Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients.

• DOI: 10.3389/fonc.2021.658004
• 发表时间: 2021
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: Konradsson E;Arendt ML;Bastholm Jensen K;Børresen B;Hansen AE;Bäck S;Kristensen AT;Munck Af Rosenschöld P;Ceberg C;Petersson K
• 通讯作者: Petersson K

Development of Ultra-High Dose-Rate (FLASH) Particle Therapy.

• DOI: 10.1109/trpms.2021.3091406
• 发表时间: 2022-03
• 期刊: IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
• 影响因子: 4.4
• 作者: Kim, Michele M.;Darafsheh, Arash;Schuemann, Jan;Dokic, Ivana;Lundh, Olle;Zhao, Tianyu;Ramos-Mendez, Jose;Dong, Lei;Petersson, Kristoffer
• 通讯作者: Petersson, Kristoffer