Pleiotropy robust Mendelian randomization

多效性稳健孟德尔随机化

• 批准号: MC_UU_00011/2
• 负责人: Jack Bowden
• 金额: $ 122.96万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00011%2F2
• 关键词: Pleiotropy; robust; Mendelian; randomization

Across the world, scientists are trying to uncover the causes of disease and ill-health, so that resources can be intelligently targeted to improve the lives of the general public. However, ethical considerations often remove the possibility of a randomized controlled trial (RCT), which is the most straightforward and reliable way of assessing causality, and decisions must be made using non-experimental data. Since our genes are randomly assigned from parents to their children at the point of conception, they should not be related to factors such as diet and other lifestyle choices that impact an individual’s health in later life. We can therefore think of them as creating a natural randomized trial. By comparing people’s health across different genetic sub-groups, we can assess whether a risk factor (e.g. cholesterol) causally influences the risk of a disease (e.g. stroke). This is technique is called Mendelian randomization. My research focuses on developing the statistical methods required to perform this analysis, so that it is reliable and efficient.

在世界范围内，科学家正试图揭示疾病和健康状况不佳的原因，以便可以智能地将资源用于改善公众的生活。但是，道德考虑通常会消除随机对照试验（RCT）的可能性，这是评估休闲性最直接，最可靠的方式，并且必须使用非实验数据做出决定。由于我们的基因是在受孕时从父母中随机分配给子女的，因此它们不应与饮食和其他影响以后生活的生活方式选择等因素有关。因此，我们可以将它们视为创建自然的随机试验。通过比较不同遗传亚组的人的健康，我们可以评估危险因素（例如胆固醇）是否会影响疾病的风险（例如中风）。这是一种称为Mendelian Randomizai的技术。我的研究重点是开发执行此分析所需的统计方法，以使其可靠和有效。

项目成果

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.

• DOI: 10.1186/s12916-020-01855-9
• 发表时间: 2020-12-17
• 期刊: BMC medicine
• 影响因子: 9.3
• 作者: Bull CJ;Bell JA;Murphy N;Sanderson E;Davey Smith G;Timpson NJ;Banbury BL;Albanes D;Berndt SI;Bézieau S;Bishop DT;Brenner H;Buchanan DD;Burnett-Hartman A;Casey G;Castellví-Bel S;Chan AT;Chang-Claude J;Cross AJ;de la Chapelle A;Figueiredo JC;Gallinger SJ;Gapstur SM;Giles GG;Gruber SB;Gsur A;Hampe J;Hampel H;Harrison TA;Hoffmeister M;Hsu L;Huang WY;Huyghe JR;Jenkins MA;Joshu CE;Keku TO;Kühn T;Kweon SS;Le Marchand L;Li CI;Li L;Lindblom A;Martín V;May AM;Milne RL;Moreno V;Newcomb PA;Offit K;Ogino S;Phipps AI;Platz EA;Potter JD;Qu C;Quirós JR;Rennert G;Riboli E;Sakoda LC;Schafmayer C;Schoen RE;Slattery ML;Tangen CM;Tsilidis KK;Ulrich CM;van Duijnhoven FJB;van Guelpen B;Visvanathan K;Vodicka P;Vodickova L;Wang H;White E;Wolk A;Woods MO;Wu AH;Campbell PT;Zheng W;Peters U;Vincent EE;Gunter MJ
• 通讯作者: Gunter MJ

Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression.

• DOI: 10.1093/ije/dyy101
• 发表时间: 2018-08-01
• 期刊: International journal of epidemiology
• 影响因子: 7.7
• 作者: Bowden J;Spiller W;Del Greco M F;Sheehan N;Thompson J;Minelli C;Davey Smith G
• 通讯作者: Davey Smith G

Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization-A Job for the Humble Heterogeneity Statistic?

• DOI: 10.1093/aje/kwy185
• 发表时间: 2018-12-01
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Bowden J;Hemani G;Davey Smith G
• 通讯作者: Davey Smith G

Realising the full potential of MR-PHeWAS in cancer.

• DOI: 10.1038/s41416-020-01165-0
• 发表时间: 2021-03
• 期刊: British journal of cancer
• 影响因子: 8.8
• 作者: Bowden J

Education, intelligence and Alzheimer's disease: evidence from a multivariable two-sample Mendelian randomization study.

• DOI: 10.1093/ije/dyz280
• 发表时间: 2020-08-01
• 期刊: International journal of epidemiology
• 影响因子: 7.7
• 作者: Anderson EL;Howe LD;Wade KH;Ben-Shlomo Y;Hill WD;Deary IJ;Sanderson EC;Zheng J;Korologou-Linden R;Stergiakouli E;Davey Smith G;Davies NM;Hemani G
• 通讯作者: Hemani G