Organelle Cross Talk and Membrane Dynamics

我们的细胞被分成不同的膜结合区室，其中一些区室形成了将物质运输进出细胞的通道。这些膜运输途径控制关键的细胞过程，包括营养摄取、活化生长因子受体的清除以及激素和神经递质的分泌。然而，我们对膜运输系统的理解仍然不完整。我们的研究整合了细胞生物学，生物化学和全系统方法，以更好地了解膜运输和细胞信号传导途径如何使细胞对环境中的线索做出反应，如生长因子，营养素和压力。我们的长期目标是开发用于治疗由膜运输缺陷引起的疾病的新疗法。

Our cells are divided into distinct membrane-bound compartments some of which form pathways that transport materials into and out of cells. These membrane trafficking pathways control key cellular processes including nutrient uptake, clearance of activated growth factor receptors, and the secretion of hormones and neurotransmitters. However our understanding of membrane trafficking systems remains incomplete. Our research integrates cell biology, biochemistry, and system-wide approaches to better understand how membrane trafficking and cell signalling pathways allow cells to respond to cues in their environment, such as growth factors, nutrients, and stress. Our long-term goal is to develop new therapeutics for the treatment of diseases caused by membrane trafficking defects.