Mitochondrial ATP synthase: cellular power generator, determinant of mitochondrial cristae formation, a site linked to human diseases

线粒体 ATP 合酶：细胞发电器、线粒体嵴形成的决定因素、与人类疾病相关的位点

• 批准号: MC_UU_00028/9
• 负责人: John Walker
• 金额: $ 49.69万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00028%2F9
• 关键词: Mitochondrial; ATP; synthase; cellular; power

Energy from the sun is entrapped by photosynthesis and stored in high energy compounds that we consume in food. The energy is released by controlled burning in the mitochondria in the cells of our bodies, and stored in the high energy compound adenosine triphosphate, ATP, the fuel of biology. ATP is made in the mitochondria inside our cells. They are “power stations” full of millions of molecular turbines, the ATP synthases that rotate like man-made turbines and churn out ATP in massive quantities.We understand how these molecular turbines work, and how rotation is generated. Now we want to understand how the activity of the mammalian enzyme is regulated, how it is put together from nineteen individual constituent proteins, and the impact on the ultrastructure of the cristae of removing individual subunits.

来自太阳的能量被光合作用捕获，并储存在我们在食物中消耗的高能化合物中。能量通过我们身体细胞中线粒体的受控燃烧释放，并储存在高能化合物三磷酸腺苷（ATP）中，ATP是生物燃料。ATP是在我们细胞内的线粒体中产生的。它们是“发电站”，充满了数以百万计的分子涡轮机，ATP酶像人造涡轮机一样旋转，并大量生产ATP。我们了解这些分子涡轮机是如何工作的，以及旋转是如何产生的。现在我们想了解哺乳动物酶的活性是如何调节的，它是如何从十九个单独的组成蛋白质组合在一起的，以及去除单个亚基对嵴的超微结构的影响。