Thematic Support - Vaccines and Immunity

专题支持 - 疫苗和免疫

• 批准号: MC_UU_00031/2
• 负责人: Beate Kampmann
• 金额: $ 317.7万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00031%2F2
• 关键词: Thematic; Support; Vaccines; Immunity

In addition to clean water, vaccines are the most powerful interventions to prevent morbidity and mortality worldwide. The research carried out in our Theme supports the implementation of safe and effective vaccines in sub-Saharan Africa, so they can be used with confidence and their delivery optimised. We also want to understand the details of how vaccines interact with the developing immune system of babies and young children, and how we might be able to use them during pregnancy to protect both the mother and/or the unborn baby against certain infectious diseases. Our clinical trials are delivering the information that is needed for licensure and trust in vaccines, and we are working closely with communities, scientists in the laboratory and public health organisations to optimise the protection for all that can be achieved through vaccination. Our tuberculosis program looks at better ways to diagnose TB in adults and children and how we can possibly predict treatment responses in order to avoid long term poor outcomes from TB and prevent transmission in the community.In all we do we work closely with the public health systems in the country and communities to make sure our research is accepted and contributes to change for better health for all.

除了清洁的水，疫苗是预防全球发病率和死亡率的最有力的干预措施。在我们的主题中进行的研究支持在撒哈拉以南非洲实施安全有效的疫苗，因此可以放心使用它们并优化其交付。我们还想了解疫苗如何与婴儿和幼儿发育中的免疫系统相互作用的细节，以及我们如何能够在怀孕期间使用它们来保护母亲和/或未出生的婴儿免受某些传染病的侵害。我们的临床试验正在提供疫苗许可和信任所需的信息，我们正在与社区，实验室科学家和公共卫生组织密切合作，以优化通过疫苗接种可以实现的所有保护。我们的结核病项目着眼于更好地诊断成人和儿童结核病的方法，以及我们如何能够预测治疗反应，以避免结核病的长期不良后果并防止在社区中传播。在我们所做的一切中，我们与国家和社区的公共卫生系统密切合作，以确保我们的研究被接受，并为改善所有人的健康做出贡献。

项目成果

Timeliness of routine childhood vaccination in 103 low-and middle-income countries, 1978-2021: A scoping review to map measurement and methodological gaps.

• DOI: 10.1371/journal.pgph.0000325
• 发表时间: 2022
• 期刊: PLOS global public health

Streptococcus pyogenes carriage acquisition, persistence and transmission dynamics within households in The Gambia (SpyCATS): protocol for a longitudinal household cohort study

冈比亚家庭内化脓性链球菌的携带获取、持久性和传播动态（SpyCATS）：纵向家庭队列研究方案

• DOI: 10.12688/wellcomeopenres.18716.1
• 发表时间: 2023
• 期刊: Wellcome Open Research
• 作者: Armitage E

Circulation of respiratory viruses during the COVID-19 pandemic in The Gambia.

冈比亚 COVID-19 大流行期间呼吸道病毒的传播。

• DOI: 10.12688/gatesopenres.14155.2
• 发表时间: 2022
• 期刊: Gates open research
• 作者: Jarju S

Making a case for investing in post-tuberculosis lung health in children.

为儿童结核病后肺部健康投资提供理由。

• DOI: 10.1016/s2213-2600(22)00102-3
• 发表时间: 2022
• 期刊: The Lancet. Respiratory medicine
• 作者: Nkereuwem E

EARLY ACQUISITION AND CARRIAGE OF GENETICALLY DIVERSE MULTI-DRUG RESISTANT GRAM-NEGATIVE BACILLI IN HOSPITALISED SMALL VULNERABLE NEWBORNS IN THE GAMBIA

冈比亚住院的小弱势新生儿早期获得和携带基因多样化的多重耐药革兰氏阴性杆菌

• DOI: 10.1101/2022.11.16.22282268
• 发表时间: 2022
• 作者: Bah S