IMPRINT: IMmunising PRegnant women and INfants neTwork
版本说明:孕妇和婴儿免疫网络
基本信息
- 批准号:MR/R005990/2
- 负责人:
- 金额:$ 286.67万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2018
- 资助国家:英国
- 起止时间:2018 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Far too many newborns continue to die in early life, particularly in low-and middle income countries (LMIC). Many die from infections, some of which could be prevented. During the late stages of pregnancy, antibody is transferred across the placenta from mother to child, providing protection to the infant in the early weeks of life. However, if the mother has insufficient protection against certain infections, the infant will also not be protected. Vaccinating women in pregnancy can enhance the level of antibody in the mother, thereby protecting the mother, and increasing the amount of antibody transferred across the placenta - protecting the infant from birth too. This concept has already been successfully established for the prevention of tetanus, influenza and pertussis (whooping cough). Many investigators and stakeholders are interested in using this strategy to protect infants from other serious infections, for example group B streptococcus or respiratory syncytial virus (RSV), and vaccines against these infections are in development. Some fundamental gaps in our understanding remain about the immune response to vaccines in pregnancy and in newborn infants which are essential for us to address in order to accelerate development of new vaccines. It is also very important that the scientific community tackles how best to implement such vaccine programmes in both high-income countries and LMIC. Our unique inter-disciplinary network represents stakeholders from basic science, immunology, vaccinology, social sciences, industry, public health and national and international policy makers who have come together in order to tackle the key challenges in the best use of vaccines in pregnancy and in newborns, and in the long term, improve maternal and newborn health. Specifically, the IMPRINT network will implement collaborative research projects to answer fundamental biological questions about antibody transfer of antibody across the placenta, how to induce the "best" antibody, and its effect on the maturing newborn immune system. We will investigate if maternal vaccines interfere with the way in which the baby responds to vaccines later in infancy and childhood, to ensure that protection is not compromised at any stage. Co-factors such as nutrition or other infections might also change the way in which mothers and infants are protected by vaccines. Hence we need to take them into consideration if we are to ensure optimal protection of vaccines in pregnancy and early life. We will also find out why women decide to receive or not to accept vaccines in different countries in order to optimise the uptake of current and new vaccines. We will endeavour to work out how vaccine safety and effectiveness can be best monitored, given the different health care systems in different countries. Addressing these implementation challenges will enable us to better understand the issues and site-preparedness in the many geographical areas and populations in which IMPRINT investigators work. IMPRINT is a multi-disciplinary network linking investigators in Europe, Africa and Asia and can therefore address these questions comprehensively. We are uniquely set up to investigate these challenges through the diversity of expertise, availability of samples and datasets already available through our collaboration, which the members are happy to share. Through our network, we will train researchers in LMIC to take forward these important questions, and we will be the forum to provide the best evidence for the safe and efficient use of vaccines in pregnancy and newborns for the ultimate goal of lowering maternal and newborn deaths from infections.
太多的新生儿继续在生命早期死亡,特别是在低收入和中等收入国家。许多人死于感染,其中一些是可以预防的。在怀孕后期,抗体通过胎盘从母亲转移到孩子身上,在生命的最初几周为婴儿提供保护。但是,如果母亲对某些感染没有足够的保护,婴儿也不会得到保护。孕妇接种疫苗可以提高母亲体内的抗体水平,从而保护母亲,并增加抗体通过胎盘转移的数量——也保护婴儿出生。在预防破伤风、流感和百日咳方面,已经成功地确立了这一概念。许多研究人员和利益相关者有兴趣使用这种策略来保护婴儿免受其他严重感染,例如B群链球菌或呼吸道合胞病毒(RSV),针对这些感染的疫苗正在开发中。我们对妊娠期和新生儿对疫苗的免疫反应的理解仍然存在一些根本性的差距,我们必须解决这些差距,以便加快新疫苗的开发。科学界解决如何最好地在高收入国家和中低收入国家实施这类疫苗规划也是非常重要的。我们独特的跨学科网络代表了来自基础科学、免疫学、疫苗学、社会科学、工业、公共卫生以及国家和国际决策者的利益攸关方,他们聚集在一起,以应对在妊娠和新生儿中最佳使用疫苗方面的关键挑战,并从长远来看,改善孕产妇和新生儿健康。具体而言,IMPRINT网络将实施合作研究项目,以回答有关抗体跨胎盘转移、如何诱导“最佳”抗体及其对成熟的新生儿免疫系统的影响等基本生物学问题。我们将调查母体疫苗是否会干扰婴儿在婴儿期和儿童期后期对疫苗的反应,以确保在任何阶段都不损害保护作用。营养或其他感染等辅助因素也可能改变疫苗保护母亲和婴儿的方式。因此,如果我们要确保在怀孕和生命早期对疫苗提供最佳保护,我们就需要考虑到这些问题。我们还将找出妇女在不同国家决定接受或不接受疫苗的原因,以优化现有疫苗和新疫苗的吸收。鉴于不同国家的卫生保健系统不同,我们将努力研究如何最好地监测疫苗的安全性和有效性。解决这些执行方面的挑战将使我们能够更好地了解“印记”调查人员工作的许多地理区域和人口中的问题和现场准备工作。IMPRINT是一个多学科网络,将欧洲、非洲和亚洲的研究人员联系起来,因此可以全面解决这些问题。通过我们的合作,我们的专业知识的多样性、样本和数据集的可用性,以及成员们乐于分享的数据集,我们有独特的设置来调查这些挑战。通过我们的网络,我们将培训低收入和中等收入国家的研究人员,以推进这些重要问题,我们将成为论坛,为在妊娠和新生儿中安全有效地使用疫苗提供最佳证据,以实现降低孕产妇和新生儿感染死亡的最终目标。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation.
- DOI:10.1016/j.vaccine.2019.11.060
- 发表时间:2020-02-24
- 期刊:
- 影响因子:5.5
- 作者:Angelidou A;Conti MG;Diray-Arce J;Benn CS;Shann F;Netea MG;Liu M;Potluri LP;Sanchez-Schmitz G;Husson R;Ozonoff A;Kampmann B;van Haren SD;Levy O
- 通讯作者:Levy O
Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life.
- DOI:10.3389/fimmu.2020.578505
- 发表时间:2020
- 期刊:
- 影响因子:7.3
- 作者:Bennike TB;Fatou B;Angelidou A;Diray-Arce J;Falsafi R;Ford R;Gill EE;van Haren SD;Idoko OT;Lee AH;Ben-Othman R;Pomat WS;Shannon CP;Smolen KK;Tebbutt SJ;Ozonoff A;Richmond PC;van den Biggelaar AHJ;Hancock REW;Kampmann B;Kollmann TR;Levy O;Steen H
- 通讯作者:Steen H
Pediatric RSV-Associated Hospitalizations Before and During the COVID-19 Pandemic.
- DOI:10.1001/jamanetworkopen.2023.36863
- 发表时间:2023-10-02
- 期刊:
- 影响因子:13.8
- 作者:Bourdeau, Malou;Vadlamudi, Nirma Khatri;Bastien, Nathalie;Embree, Joanne;Halperin, Scott A.;Jadavji, Taj;Kazmi, Kescha;Langley, Joanne M.;Lebel, Marc H.;Le Saux, Nicole;Moore, Dorothy;Morris, Shaun K.;Pernica, Jeffrey M.;Robinson, Joan;Sadarangani, Manish;Bettinger, Julie A.;Papenburg, Jesse
- 通讯作者:Papenburg, Jesse
HIV and SARS-CoV-2 infection in postpartum Kenyan women and their infants.
- DOI:10.1371/journal.pone.0278675
- 发表时间:2023
- 期刊:
- 影响因子:3.7
- 作者:Begnel, Emily R.;Chohan, Bhavna H.;Ojee, Ednah;Adhiambo, Judith;Owiti, Prestone;Ogweno, Vincent;Holland, LaRinda A.;Fish, Carolyn S.;Richardson, Barbra A.;Khan, Adam K.;Maqsood, Rabia;Lim, Efrem S.;Sadarangani, Manish;Lehman, Dara A.;Slyker, Jennifer;Kinuthia, John;Wamalwa, Dalton;Gantt, Soren
- 通讯作者:Gantt, Soren
BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
- DOI:10.1126/scitranslmed.aax4517
- 发表时间:2020-05-06
- 期刊:
- 影响因子:17.1
- 作者:Brook B;Harbeson DJ;Shannon CP;Cai B;He D;Ben-Othman R;Francis F;Huang J;Varankovich N;Liu A;Bao W;Bjerregaard-Andersen M;Schaltz-Buchholzer F;Sanca L;Golding CN;Larsen KL;Levy O;Kampmann B;EPIC Consortium;Tan R;Charles A;Wynn JL;Shann F;Aaby P;Benn CS;Tebbutt SJ;Kollmann TR;Amenyogbe N
- 通讯作者:Amenyogbe N
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Beate Kampmann其他文献
Multi-level determinants of timely routine childhood vaccinations in The Gambia: Findings from a nationwide analysis
- DOI:
10.1016/j.vaccine.2024.126500 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:
- 作者:
Oghenebrume Wariri;Chigozie Edson Utazi;Uduak Okomo;Winfred Dotse-Gborgbortsi;Malick Sogur;Sidat Fofana;Kris A. Murray;Chris Grundy;Beate Kampmann - 通讯作者:
Beate Kampmann
Uptake of macrophage exosomes by the human placenta.
- DOI:
10.1016/j.placenta.2014.06.191 - 发表时间:
2014-09-01 - 期刊:
- 影响因子:
- 作者:
Beth Holder;Tessa Jones;Sandra Okala;Karen Forbes;Beate Kampmann - 通讯作者:
Beate Kampmann
Maternal and infant factors linked with rotavirus vaccine outcome in three continents
三大洲的母婴因素与轮状病毒疫苗结果相关
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Edward P. K. Parker;C. Bronowski;K. Sindhu;S. Babji;B. Benny;N. Carmona;Nedson Chasweka;End Chinyama;Nigel A Cunliffe;Queen Dube;S. Giri;N. Grassly;Annai Gunasekaran;Deborah Howarth;5. Sushil;Immanuel;K. Jere;Beate Kampmann;Jenna Lowe;J. Mandolo;Ira Praharaj;B. S. Rani;S. Silas;V. Srinivasan;Mark Turner;7. Srinivasan;Venugopal;V. Verghese;A. Darby;Gagandeep Kang;M. Iturriza - 通讯作者:
M. Iturriza
Diagnostics for childhood tuberculosis: a marathon rather than a sprint.
儿童结核病的诊断:一场马拉松而不是短跑。
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
T. Togun;Beate Kampmann - 通讯作者:
Beate Kampmann
Anticipating the impact of the COVID-19 pandemic on TB patients and TB control programmes
- DOI:
10.1186/s12941-020-00363-1 - 发表时间:
2020-05-23 - 期刊:
- 影响因子:3.600
- 作者:
Toyin Togun;Beate Kampmann;Neil Graham Stoker;Marc Lipman - 通讯作者:
Marc Lipman
Beate Kampmann的其他文献
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{{ truncateString('Beate Kampmann', 18)}}的其他基金
Immunising Pregnant women and infants network- IMPRINT
孕妇和婴儿免疫网络- IMPRINT
- 批准号:
MR/Y033752/1 - 财政年份:2023
- 资助金额:
$ 286.67万 - 项目类别:
Research Grant
Thematic Support - Vaccines and Immunity
专题支持 - 疫苗和免疫
- 批准号:
MC_UU_00031/2 - 财政年份:2022
- 资助金额:
$ 286.67万 - 项目类别:
Intramural
IMPRINT: IMmunising PRegnant women and INfants neTwork
版本说明:孕妇和婴儿免疫网络
- 批准号:
MC_PC_17221 - 财政年份:2018
- 资助金额:
$ 286.67万 - 项目类别:
Intramural
Evaluating novel diagnostics and enabling preventive measures for childhood tuberculosis between the UK and partners in Sub-Saharan Africa
英国与撒哈拉以南非洲合作伙伴之间评估儿童结核病的新型诊断方法和实施预防措施
- 批准号:
MC_EX_MR/P024270/1 - 财政年份:2017
- 资助金额:
$ 286.67万 - 项目类别:
Research Grant
IMPRINT: IMmunising PRegnant women and INfants neTwork
版本说明:孕妇和婴儿免疫网络
- 批准号:
MR/R005990/1 - 财政年份:2017
- 资助金额:
$ 286.67万 - 项目类别:
Research Grant
Childhood tuberculosis: Integrating tools for improved diagnosis and vaccines
儿童结核病:整合工具以改进诊断和疫苗
- 批准号:
MC_EX_MR/K011944/1 - 财政年份:2013
- 资助金额:
$ 286.67万 - 项目类别:
Research Grant
相似海外基金
Immunising Pregnant women and infants network- IMPRINT
孕妇和婴儿免疫网络- IMPRINT
- 批准号:
MR/Y033752/1 - 财政年份:2023
- 资助金额:
$ 286.67万 - 项目类别:
Research Grant
IMPRINT: IMmunising PRegnant women and INfants neTwork
版本说明:孕妇和婴儿免疫网络
- 批准号:
MC_PC_17221 - 财政年份:2018
- 资助金额:
$ 286.67万 - 项目类别:
Intramural
IMPRINT: IMmunising PRegnant women and INfants neTwork
版本说明:孕妇和婴儿免疫网络
- 批准号:
MR/R005990/1 - 财政年份:2017
- 资助金额:
$ 286.67万 - 项目类别:
Research Grant
Immunising Aboriginal mothers with pneumococcal polysaccharide vaccine to prevent infant ear disease and carriage
为原住民母亲接种肺炎球菌多糖疫苗,以预防婴儿耳病和携带
- 批准号:
nhmrc : 350499 - 财政年份:2005
- 资助金额:
$ 286.67万 - 项目类别:
NHMRC Project Grants