Immunising Pregnant women and infants network- IMPRINT

孕妇和婴儿免疫网络- IMPRINT

• 批准号: MR/Y033752/1
• 负责人: Beate Kampmann
• 金额: $ 161.24万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FY033752%2F1
• 关键词: Immunising; Pregnant; women; infants; network

The IMmunising PRegnant women and INfants neTwork (IMPRINT) is one of the five vaccine networks funded by UKRI/GCRF. Vaccines can make a significant contribution to the health and survival of newborn babies, young children and their mothers. Vaccination in pregnancy benefits both the mother and baby - both before and after birth. Vaccines protecting against tetanus, flu, whooping cough and COVID-19 are recommended for use in pregnancy. Vaccines stimulate the immune system to produce antibodies which protect the pregnant woman against infection and also protect her baby for several months after delivery and during the time the baby is most vulnerable to severe infection. New vaccines for this specific purpose have just been licensed (RSV) or are on the horizon (Group B strep, Lassa fever). Our network activities relate to tackling the biological and implementation challenges for maternal and neonatal immunisation. We achieve this through a) conducting research into the placenta and how the antibody passes to the baby before birth and its impact on the maturing neonatal immune system using state-of-the art novel technologies, b) through training and capacity building and networking for interdisciplinary researchers in low- and high-income countries, and c) via the integration of public voices and health systems assessments to deliver this successful intervention to those who ultimately require to be protected. Our work to date has laid solid foundations and we have become an internationally recognised network with leading expertise in this area and a partner to other international organisations with direct impact on policy. Our unique selling point is to be able to relate our evidence-based research results and implementation strategies to the many situations on the ground in HIC and LMIC countries, given the diversity and reach of our membership.

怀孕妇女和婴儿免疫网络是由UKRI/GCRF资助的五个疫苗网络之一。疫苗可以为新生儿、幼儿及其母亲的健康和生存做出重大贡献。怀孕期间接种疫苗对母亲和婴儿都有好处-无论是在出生前还是出生后。建议孕妇接种预防破伤风、流感、百日咳和COVID-19的疫苗。疫苗刺激免疫系统产生抗体，保护孕妇免受感染，并在分娩后的几个月内保护婴儿，以及婴儿最容易受到严重感染的时期。用于这一特定目的的新疫苗刚刚获得许可（RSV）或即将问世（B组链球菌、拉沙热）。我们的网络活动涉及应对孕产妇和新生儿免疫接种的生物学和实施挑战。我们通过以下方式实现这一目标：a）利用最先进的新技术，对胎盘进行研究，研究抗体如何在出生前传递给婴儿，及其对成熟的新生儿免疫系统的影响，B）通过培训和能力建设，以及为低收入和高收入国家的跨学科研究人员建立网络，以及c）通过整合公众意见和卫生系统评估，向最终需要保护的人提供这种成功的干预措施。迄今为止，我们的工作奠定了坚实的基础，我们已成为国际公认的网络，在这一领域拥有领先的专业知识，并成为其他国际组织的合作伙伴，对政策产生直接影响。我们的独特卖点是能够将我们的循证研究成果和实施战略与高收入国家和低收入国家的许多实际情况联系起来，因为我们的成员具有多样性和影响力。