Immunopsychiatry: Investigating the role of inflammation in depression and other psychiatric disorders

免疫精神病学：研究炎症在抑郁症和其他精神疾病中的作用

• 批准号: MC_UU_00032/6
• 负责人: Golam Khandaker
• 金额: $ 197.76万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00032%2F6
• 关键词: Immunopsychiatry; Investigating; role; inflammation; depression

Mental illnesses affect one in four people in the lifetime, but current treatments for depression are ineffective for up to one in three people. Therefore, there is an urgent need for developing new and more targeted treatments. Our research focuses on the role of inflammation (overactivity of one component of the immune system) in depression to better understand how this condition develops and in whom. We use large-scale population data on psychiatric symptoms, genetic make-up, and blood-based biomarkers to examine whether: i) inflammation could be a cause for depression; ii) possible side effects of supressing immune pathways; iii) inflammation could be a common cause for >1 psychiatric conditions; and iv) there are inflammation related subgroup(s) within depression. Answers to these questions will help us to develop new and more targeted treatment for depression.

精神疾病影响四分之一的人的一生，但目前的抑郁症治疗方法对三分之一的人无效。因此，迫切需要开发新的和更有针对性的治疗方法。我们的研究重点是炎症（免疫系统的一个组成部分的过度活跃）在抑郁症中的作用，以更好地了解这种情况是如何发展的，以及在谁身上。我们使用关于精神症状，遗传组成和血液生物标志物的大规模人群数据来检查：i）炎症是否可能是抑郁症的原因; ii）抑制免疫途径的可能副作用; iii）炎症可能是>1精神疾病的常见原因; iv）抑郁症中存在炎症相关亚组。这些问题的答案将有助于我们开发新的、更有针对性的抑郁症治疗方法。

项目成果

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study.

• DOI: 10.1371/journal.pmed.1004174
• 发表时间: 2023-01
• 期刊: PLoS medicine
• 影响因子: 15.8

Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis.

精神病免疫机制分层药物（PIMS）试验的方案：一项在精神病患者中单剂量tocilizumab的随机双盲安慰剂对照试验。

• DOI: 10.1136/bmjopen-2022-067944
• 发表时间: 2023-03-24
• 期刊: BMJ open
• 影响因子: 2.9

Genomic insights into the comorbidity between type 2 diabetes and schizophrenia

• DOI: 10.1038/s41537-024-00445-5
• 发表时间: 2024-02-21
• 期刊: SCHIZOPHRENIA
• 作者: Arruda，Ana Luiza;Khandaker，Golam M.;Zeggini，Eleftheria
• 通讯作者: Zeggini，Eleftheria

Relationship between Polyunsaturated Fatty Acids and Inflammation: evidence from cohort and Mendelian randomization analyses

多不饱和脂肪酸与炎症之间的关系：来自队列和孟德尔随机分析的证据

• DOI: 10.1101/2023.11.27.23299099
• 发表时间: 2023
• 作者: Crick D

Comparison of the stability of Glycoprotein Acetyls and high sensitivity C-reactive protein as markers of chronic inflammation

糖蛋白乙酰基和高敏 C 反应蛋白作为慢性炎症标志物的稳定性比较

• DOI: 10.1101/2023.03.02.23286349
• 发表时间: 2023
• 作者: Crick D