Enhancer function and dysfunction: molecular mechanisms, genome context, and disease

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The complexity of our development, health and disease is dependent on the precise way that our genes are controlled. This is driven by genetic switches embedded in the 95% of our genome that does not contain genes – the so-called non-coding genome. Mutations in these switches can cause severe disease but we do not understand how. This programme aims to investigate how the three-dimensional folding of the genome underpins how these genetic switches work and to improve our understanding of how genetic changes in these genetic elements contributes to disease and disease risk.