PILOT STUDY OF PACLITAXEL WITH RADIOTHERAPY FOR ADVANCED HEAD AND NECK CANCER

紫杉醇联合放疗治疗晚期头颈癌的试点研究

• 批准号: 5201329
• 负责人: L HERSCHER
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201329
• 关键词: basosquamous cell carcinoma; cell cycle; combination cancer therapy; drug adverse effect; drug tolerance; head /neck neoplasm; human subject; human therapy evaluation; injection /infusion; neoplasm /cancer chemotherapy; neoplasm /cancer classification /staging; oral pharyngeal neoplasm; paclitaxel; radiation therapy; radiobiology

This is a pilot study designed to evaluate the toxicity of a five-day infusion of paclitaxel concurrent with radiation therapy for advanced head and neck cancers. Patients with previously untreated stage III and IV squamous cell cancer of the oral cavity, oropharynx, hypopharynx, larynx, and maxillary sinus as well as stage II squamous cell cancers of the base of tongue and maxillary sinus are eligible. Tolerance of the regimen will be evaluated by using RTOG and CTEP standard toxicity criteria and by median elapsed treatment time. Serial tumors will be obtained to measure tumor potential doubling time and biological effects of treatment on the cell cycle.

这是一项试点研究，旨在评估为期五天的毒性 晚期头部输注紫杉醇联合放射治疗 和颈部癌症。先前未经治疗的 III 期和 IV 期患者 口腔、口咽、下咽、喉的鳞状细胞癌， 和上颌窦以及 II 期基底鳞状细胞癌 舌和上颌窦均符合条件。该方案的耐受性将 使用 RTOG 和 CTEP 标准毒性标准进行评估 中位治疗时间。 将获得连续肿瘤来测量 肿瘤电位倍增时间和治疗的生物学效应 细胞周期。