ORAL PHYSIOLOGY OF AGING

衰老的口腔生理学

• 批准号: 5201820
• 负责人: C F STRECKFUS
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201820
• 关键词: adolescence (12-20); aging; biomarker; child (0-11); dental alveolus; dental disorder diagnosis; dental research; diagnosis design /evaluation; disease /disorder proneness /risk; early diagnosis; epidemiology; human data; human subject; longitudinal human study; oral health; pathologic bone resorption

The oral research component of the Baltimore Longitudinal Study of Aging (BLSA), since its inception in 1978, has been designed and conducted by the NIDR to evaluate the physiological and pathological factors that influence the oral health and function of individuals of different ages. The BLSA is a large longitudinal study with an open-panel design conducted by the National Institute on Aging to investigate a range of scientific hypotheses about the aging process. Human volunteers return periodically to the BLSA site to undergo multiple health assessments including the oral health evaluation made by Branch staff. The Division of Epidemiology and Oral Disease Prevention has broadened the scope of the oral research component to include studies of alveolar bone loss in the oral cavity, the detection and application of oral molecular biological markers for systemic disease, and an expanded periodontal evaluation implementing protein markers and DNA microbial probes for early disease detection. The oral epidemiology component is also working with the BLSA to increase minority enrollment thereby increasing the diversity of the study's population base. The implementation of these additional areas of investigation within the BLSA, present an opportunity to enhance the overall understanding of age related changes in the oral cavity.

巴尔的摩老龄化纵向研究的口头研究部分 (BLSA)自1978年成立以来，一直由 NIDR评估生理和病理因素 影响不同年龄个体的口腔健康和口腔功能。 BLSA是一项大型纵向研究，采用开放面板设计 由国家老龄化研究所调查一系列科学 关于衰老过程的假说。人类志愿者定期返回 到BLSA现场接受多项健康评估，包括口腔 分公司员工进行的健康评估。流行病学和医学部 口腔疾病预防拓宽了口腔研究的范围 组件以包括对口腔中牙槽骨丢失的研究， 口服液分子生物学标志物的检测及应用 系统性疾病和扩展牙周评估的实施 蛋白质标记物和DNA微生物探针用于疾病早期检测。这个 口腔流行病学部门也在与BLSA合作，以增加 少数族裔入学，从而增加了研究的多样性 人口基数。这些额外领域的实施 BLSA内部的调查提供了一个机会，以加强 全面了解口腔中与年龄相关的变化。