ORAL PHYSIOLOGY OF AGING

衰老的口腔生理学

• 批准号: 3775735
• 负责人: C F STRECKFUS
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775735
• 关键词: aging; biomarker; dental alveolus; dental disorder diagnosis; dental research; diagnosis design /evaluation; early diagnosis; epidemiology; human data; oral health; pathologic bone resorption

The oral research component of the Baltimore Longitudinal Study of Aging (BLSA), since its inception in 1978, has been designed to evaluate the physiological and pathological factors that influence the oral health and function of individuals of different ages. Currently, the EODPP, is developing plans to broaden the scope of research to include studies of alveolar bone loss in the oral cavity, the detection and application of oral molecular biological markers for systemic disease, and an expanded periodontal evaluation implementing protein markers and DNA microbial probes for early disease detection. The oral epidemiology component is also working with the BLSA to increase minority enrollment thereby increasing the diversity of the BLSA population base. The implementation of these additional areas of investigation within the BLSA, present an opportunity to enhance the overall understanding of age related changes in the oral cavity.

巴尔的摩纵向研究的口腔研究部分， 老龄化（BLSA）自1978年成立以来，一直致力于 评估影响其生理和病理因素， 不同年龄的人的口腔健康和功能。 目前， EODPP正在制定计划，以扩大研究范围， 包括口腔中牙槽骨丢失的研究， 口腔分子生物学标记物在系统性 疾病，和一个扩大的牙周评估实施蛋白质 标记和DNA微生物探针用于早期疾病检测。口腔 流行病学部分还与BLSA合作， 少数民族入学，从而增加BLSA的多样性 人口基数。这些额外领域的实施 在BLSA内部进行调查，提供了一个机会，以加强 全面了解与年龄有关的口腔变化。