Driving up the quality and relevance of research-based knowledge through the identification and use of core outcomes: the COMET Initiative

通过识别和使用核心成果来提高基于研究的知识的质量和相关性：COMET 计划

• 批准号: MR/J004847/1
• 负责人: Paula Williamson
• 金额: $ 22.21万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FJ004847%2F1
• 关键词: Driving; up; quality; relevance; research

People doing clinical trials and other types of health research often struggle when trying to choose the outcomes to measure which would be of most use to the patients, practitioners and policy makers who will use their research to help them make decisions. These difficulties for trialists are passed on to those producing and reading systematic reviews of trials, many of whom have experienced the frustration of finding that the original researchers either did not measure certain outcomes or measured them in such different ways that it is difficult or impossible to compare, contrast or combine the studies. Much could be gained if there was an agreed minimum set of core outcomes for each medical condition, which were measured and reported in all clinical trials in that area. Last year, the COMET Initiative was launched to bring together an international network of individuals and organisations interested in the development, application and promotion of such core outcome sets. COMET aims to collate relevant resources in a publically available, searchable database; to provide guidance on methods for developing core outcome sets; and to develop reporting standards for such studies. Through personal contacts we already know of work on core outcome sets in over 70 areas but there is likely to be much more than this. This proposal is for a two year project to consolidate and develop the COMET Initiative, that has started and that is supported by many stakeholders. The project will include three workstreams: core activity, research, and strategic development. Core activity will include periodic searching of the literature to identify all relevant work and keep the database up to date, provision of advice to researchers, delivery of training workshops, collation of information about methodological research, organisation of international meetings, and development of the website as a resource for those interested in outcome measurement. We will also examine the level and nature of any patient involvement in this work, since examples exist where patients have identified an outcome important to them as a group that might not have been considered if the core outcome set was developed by practitioners on their own. An initial review of the studies identified to date shows that the methods used to develop core outcome sets vary and there is limited empirical evidence regarding whether different methods result in similar or different conclusions. Our research will involve undertaking a survey of researchers to understand their experience of core outcome set development and their choice of approach. From the survey, we will identify key methodological research questions and subsequently undertake feasibility work alongside ongoing core outcome set development in particular clinical areas.This workstream will provide a starting point for methodological research in this area, with the goal of improving methodological standards for COS development.Our strategic development will involve working towards three main goals: (i) to increase the number of core outcome sets developed using evidence-based methods, (ii) to increase their impact on the quality of research-based knowledge, by raising awareness and increasing implementation, and (iii) to establish methods for standards of core outcome set development.

进行临床试验和其他类型的健康研究的人往往难以选择结果来衡量哪些结果对患者、从业者和政策制定者最有用，他们将利用他们的研究帮助他们做出决定。试验者的这些困难被传递给那些制作和阅读试验系统评价的人，他们中的许多人都经历过沮丧，因为他们发现最初的研究人员要么没有衡量某些结果，要么以如此不同的方式衡量它们，以至于很难或不可能比较、对比或合并这些研究。如果为每种疾病设定一个商定的最低核心结果集，并在该领域的所有临床试验中对其进行衡量和报告，则可以获得很大收获。去年，发起了COMET倡议，将对开发、应用和促进这种核心成果集感兴趣的个人和组织的国际网络聚集在一起。COMET的目标是在一个公开的、可搜索的数据库中整理相关资源；就制定核心成果集的方法提供指导；并为这类研究制定报告标准。通过个人接触，我们已经了解到70多个领域的核心成果集方面的工作，但可能还有更多的工作。这项提案是一个为期两年的项目，旨在巩固和发展彗星倡议，该项目已经启动，并得到了许多利益攸关方的支持。该项目将包括三个工作流程：核心活动、研究和战略发展。核心活动将包括定期检索文献，以确定所有相关工作并使数据库保持最新，向研究人员提供咨询意见，举办培训讲习班，整理有关方法研究的信息，组织国际会议，并开发网站，作为对成果衡量感兴趣的人的资源。我们还将检查任何患者参与这项工作的水平和性质，因为存在这样的例子，即患者作为一个群体确定了对他们重要的结果，如果核心结果集是由从业者自己制定的，可能不会被考虑。对迄今确定的研究的初步审查表明，用于制定核心成果集的方法各不相同，关于不同方法得出类似或不同结论的经验证据有限。我们的研究将涉及对研究人员进行调查，以了解他们在核心结果集开发方面的经验和他们选择的方法。从调查中，我们将确定关键的方法学研究问题，并随后在特定临床领域进行正在进行的核心结果集开发的可行性工作。这一工作流程将为这一领域的方法学研究提供一个起点，目标是改进COS开发的方法学标准。我们的战略发展将涉及努力实现三个主要目标：(I)增加使用循证方法开发的核心结果集的数量，(Ii)通过提高认识和加强实施，增加它们对基于研究的知识质量的影响，以及(Iii)建立核心结果集开发标准的方法。

项目成果

Choosing important health outcomes for comparative effectiveness research: a systematic review.

• DOI: 10.1371/journal.pone.0099111
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Gargon E;Gurung B;Medley N;Altman DG;Blazeby JM;Clarke M;Williamson PR
• 通讯作者: Williamson PR

Core outcome sets and trial registries.

• DOI: 10.1186/s13063-015-0738-6
• 发表时间: 2015-05-14
• 期刊: Trials
• 影响因子: 2.5
• 作者: Clarke M;Williamson P
• 通讯作者: Williamson P

COS-STAR: a reporting guideline for studies developing core outcome sets (protocol).

COS-Star：开发核心结果集（协议）的研究指南。

• DOI: 10.1186/s13063-015-0913-9
• 发表时间: 2015-08-22
• 期刊: Trials
• 影响因子: 2.5
• 作者: Kirkham JJ;Gorst S;Altman DG;Blazeby J;Clarke M;Devane D;Gargon E;Williamson PR;COS-STAR Group
• 通讯作者: COS-STAR Group

The need for consensus, consistency, and core outcome sets in perioperative research.

围手术期研究需要达成共识、一致性和核心结果。

• DOI: 10.1007/s12630-015-0529-2
• 发表时间: 2016
• 期刊: Canadian journal of anaesthesia = Journal canadien d'anesthesie
• 作者: Blazeby JM

Core outcome sets and systematic reviews.

• DOI: 10.1186/s13643-016-0188-6
• 发表时间: 2016-01-20
• 期刊: Systematic reviews
• 影响因子: 3.7
• 作者: Clarke M;Williamson PR
• 通讯作者: Williamson PR