Centre for Molecular Bacteriology and Infection

分子细菌学和感染中心

• 批准号: MR/J006874/1
• 负责人: David Holden
• 金额: $ 492.89万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FJ006874%2F1
• 关键词: Centre; Molecular; Bacteriology; Infection

Bacterial infections continue to cause immense human suffering and mortality throughout the world. The incidence of some 'old' diseases such as tuberculosis has risen dramatically in recent years and important new infections have emerged. We lack efficacious vaccines for many bacterial diseases and the alarming worldwide rise in antibiotic-resistant bacterial pathogens continues unabated. Surprisingly, despite its importance, there are no centres of excellence focussing exclusively on bacterial infection research (either in the UK or overseas) and there is a widespread concern about the shortage of UK-trained academics and clinicians developing research careers in bacterial infection biology. The Centre for Molecular Microbiology and Infection (CMMI) at Imperial College London consists of eleven independent research teams all working on different aspects of bacterial infection. Over the last decade these teams have made major contributions to our understanding of the nature of bacterial virulence at the cellular, molecular and structural levels. The purpose of this application is to take advantage of exciting recent progress in bacterial infection biology to strengthen our current research portfolio and expand our interests to tackle important under-researched subjects that are complementary to our ongoing work. To achieve this, we wish to create an MRC-supported Centre for Molecular Bacteriology and Infection (CMBI). Imperial College will contribute by making available six new lectureship posts to study issues such as persistence and antibiotic resistance in bacterial pathogens in hospitals, host immune mechanisms and bacterial strains that cause disease in the developing world. To increase our ability to do leading edge research we are requesting new equipment and support posts from the MRC that will enable us to study the processes of infection and host responses in living tissues, and to purify and analyze important bacterial proteins at the molecular level. These studies will bring a deeper understanding of the processes that underlie bacterial pathogenesis and will suggest new approaches to develop anti-bacterial drugs and rationally designed vaccines against bacterial infections. The new Centre will have strong collaborations with academic, clinical and industrial colleagues outside the Centre who work on other aspects of bacterial disease, and with whom we can share expertise. A very important element of this application is to take advantage of the excellent research environment and expertise within our Centre to provide basic science training in the form of PhDs. The training programmes offered by the CMBI will cover four major functions: (1) The training of academic bacterial infection biologists through a "1+3 year" combined MRes-PhD programme; (2) To enable students on the Imperial College six-year undergraduate medical course to undertake a 3 year MD-PhD in bacterial infection biology as part of their course; (3) To provide clinically qualified professionals (at specialty registrar level) with research training in bacterial infection biology through dedicated PhD training fellowships. This will provide clinical academics with the knowledge and analytical skills that will enable them to integrate basic science with practical medicine to pursue high quality and clinically relevant independent research in the field of bacterial infection biology.

细菌感染继续在全世界造成巨大的人类痛苦和死亡。近年来，结核病等一些“老”疾病的发病率急剧上升，并且出现了重要的新感染。我们缺乏针对许多细菌性疾病的有效疫苗，并且全球范围内耐抗生素细菌病原体的惊人增长有增无减。令人惊讶的是，尽管细菌感染研究很重要，但并没有专门专注于细菌感染研究的卓越中心（无论是在英国还是海外），而且人们普遍担心缺乏在英国培训的学者和临床医生在细菌感染生物学方面开展研究事业。伦敦帝国理工学院分子微生物学和感染中心 (CMMI) 由 11 个独立研究小组组成，他们都致力于细菌感染的不同方面。在过去的十年中，这些团队为我们在细胞、分子和结构水平上理解细菌毒力的本质做出了重大贡献。此应用程序的目的是利用细菌感染生物学方面令人兴奋的最新进展来加强我们当前的研究组合，并扩大我们的兴趣，以解决与我们正在进行的工作相补充的重要的未充分研究的课题。为了实现这一目标，我们希望创建一个由 MRC 支持的分子细菌学和感染中心 (CMBI)。帝国理工学院将提供六个新的讲师职位来研究诸如医院细菌病原体的持久性和抗生素耐药性、宿主免疫机制以及在发展中国家引起疾病的细菌菌株等问题。为了提高我们进行前沿研究的能力，我们向 MRC 请求新的设备和支持站，这将使我们能够研究活体组织中的感染过程和宿主反应，并在分子水平上纯化和分析重要的细菌蛋白质。这些研究将更深入地了解细菌发病机制的过程，并将提出开发抗菌药物和合理设计针对细菌感染的疫苗的新方法。新中心将与中心外从事细菌性疾病其他方面研究的学术、临床和工业同事进行强有力的合作，我们可以与他们分享专业知识。该申请的一个非常重要的要素是利用我们中心优良的研究环境和专业知识，以博士的形式提供基础科学培训。 CMBI的培养项目将涵盖四大功能：（1）通过“1+3年”的MRes-PhD联合培养学术细菌感染生物学家； (2) 让帝国理工学院六年制本科医学课程的学生能够攻读为期三年的细菌感染生物学医学博士-博士学位，作为课程的一部分； (3) 通过专门的博士培训奖学金，为临床合格的专业人员（专业注册员级别）提供细菌感染生物学的研究培训。这将为临床学者提供知识和分析技能，使他们能够将基础科学与实用医学相结合，在细菌感染生物学领域追求高质量和临床相关的独立研究。

项目成果

Setting up and monitoring an infection of Dictyostelium discoideum with mycobacteria.

• DOI: 10.1007/978-1-62703-302-2_22
• 发表时间: 2013-01-01
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Arafah, Sonia;Kicka, Sebastien;Soldati, Thierry
• 通讯作者: Soldati, Thierry

Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase.

• DOI: 10.1093/jac/dkt155
• 发表时间: 2013-09
• 期刊: The Journal of antimicrobial chemotherapy
• 作者: Andreu N;Zelmer A;Sampson SL;Ikeh M;Bancroft GJ;Schaible UE;Wiles S;Robertson BD
• 通讯作者: Robertson BD