BASIC FIBROBLAST GROWTH FACTOR AND MYOCARDIAL ANGIOGENESIS
碱性成纤维细胞生长因子和心肌血管生成
基本信息
- 批准号:5203598
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Several polypeptide growth factors have been identified with the ability
to induce blood vessel development (angiogenesis), and the overall
project goal is to utilize such growth factors to facilitate coronary
collateral development in patients with ischemic heart disease. We have
shown that basic fibroblast growth factor (bFGF) and vascular
endothelial growth factor, both angiogenic polypeptide growth factors,
enhance coronary collateral development in dogs when administered
repeatedly into the coronary circulation, or, in the case of bFGF, when
administered daily into the systemic arterial circulation for seven
days. These routes of administration, although acceptable in
experimental animals, are not practical in human subjects. Most
recently, we have shown that two single doses of bFGF administered into
the left main coronary artery enhance coronary collateral flow in dogs,
a regimen that would be feasible in human subjects. Dogs were subjected
to gradual occlusion of the left circumflex coronary artery and
randomized to receive bFGF 100 micrograms/kg or a vehicle control as an
intracoronary bolus on one or two occasions (2 days between doses).
Collateral perfusion was assessed during maximal coronary vasodilatation
17 days after treatment. Maximal collateral flow in dogs that received
two doses of bFGF exceeded that of control dogs by 39% (P<0.0005).
Based on these and a number of earlier investigations, we have obtained
an IND (Investigational New Drug) for a Phase I study in human subjects.
This is a randomized, double-blind safety study with a typical dose
escalation format in which bFGF (or vehicle) is administered into the
coronary circulation. The first patients entered into the study in
July, 1995. Additional preclinical studies are underway to assess the
potential of gene therapy to effect coronary angiogenesis. Gene therapy
represents an attractive alternative to the administration of
polypeptide growth factors. Sustained local expression of angiogenic
gene products could result in site-specific angiogenic stimulation
following a single intracoronary treatment.
几种多肽生长因子已被确定具有这种能力
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('E UNGER', 18)}}的其他基金
A MODEL OF ARTERIAL SMOOTH MUSCLE CELL PROLIFERATION TO STUDY RESTENOSIS
用于研究再狭窄的动脉平滑肌细胞增殖模型
- 批准号:
3843381 - 财政年份:
- 资助金额:
-- - 项目类别:
PROMOTION OF MYOCARDIAL ANGIOGENESIS USING PEPTIDE GROWTH FACTORS
利用肽生长因子促进心肌血管生成
- 批准号:
3843382 - 财政年份:
- 资助金额:
-- - 项目类别:
A MODEL OF ARTERIAL SMOOTH MUSCLE CELL PROLIFERATION TO STUDY RESTENOSIS
用于研究再狭窄的动脉平滑肌细胞增殖模型
- 批准号:
3858120 - 财政年份:
- 资助金额:
-- - 项目类别:
PROMOTION OF MYOCARDIAL ANGIOGENESIS USING PEPTIDE GROWTH FACTORS
利用肽生长因子促进心肌血管生成
- 批准号:
3779616 - 财政年份:
- 资助金额:
-- - 项目类别:
PROMOTION OF MYOCARDIAL ANGIOGENESIS VIA DIRECT APPLICATION OF FGF TO HEART
通过直接将 FGF 应用于心脏促进心肌血管生成
- 批准号:
3858121 - 财政年份:
- 资助金额:
-- - 项目类别:
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