EPICure@19 - the extremely preterm young adult

EPICure@19 - 极度早产的年轻人

• 批准号: MR/J01107X/1
• 负责人: Neil Marlow
• 金额: $ 234.02万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FJ01107X%2F1
• 关键词: EPICure; 19; extremely; preterm; young

The EPICure study was established in 1995. All births between 20 and 25 weeks of gestation across the United Kingdom and Ireland were identified in a 10-month period. There were 309 surviving children from 4004 births, who have been followed up at 2 1/2, 6 and 11 years of age. The information from this study has been used to derive a range of policy and treatment options for extremely preterm babies. In view of the findings at 11y of continuing high rates of disability, learning problems, respiratory problems and psychological disturbances, and the suggestion from other more mature cohorts that adolescence may be a period of catch up, we propose to re-evaluate the subjects as young adults at 19 years. The reasons we need to do this are to see whether there has been catch up in terms of their development and to evaluate the longer-term effect of changes we have defined in respiratory function and cardiovascular development, which may have important long-term consequences for their adult life. Given the independence of the young people in the study we will arrange an appointment at the Study centre, based at UCL in Central London. This will allow us to carry out better assessments including a brain MR Scan.We will evaluate the following areas of functioning: cognition, executive function (attention, processing of information), memory, behaviour, respiratory function and blood vessel stiffness, and sensory thresholds. Our MRI scan will allow us to relate structural and functional measures to these outcomes using state-of-the-art analyses. In addition we will undertake a lifestyle interview with each child.The importance of these evaluations is several fold: we will be assessing children at the peak of their physical performance as they transition to adult life making this the best time to assess the effects of being born so early on growth, lungs and blood vessels and to work out how accurate our childhood assessments of these were; secondly we can evaluate how predictive our assessments of cognitive and executive performance were in childhood, or to what extent there is catch up over the teenage years; thirdly we can work out which are the key outcomes in adult life that matter and look back at the early life measures we have already collected and suggest better focused targeting of interventions to improve the young adult outcomes.

EPICure研究成立于1995年。在英国和爱尔兰，所有怀孕20至25周的新生儿都在10个月内被确认。4004名新生儿中有309名幸存下来，他们分别在2岁半、6岁和11岁时接受了随访。这项研究的信息已被用于为极度早产儿制定一系列政策和治疗方案。鉴于2011年的研究结果，残疾、学习问题、呼吸问题和心理障碍的发生率持续较高，以及其他更成熟的队列的建议，即青春期可能是一个追赶期，我们建议在19岁时重新评估这些对象。我们需要这样做的原因是，看看他们的发育是否已经赶上了，并评估我们所定义的呼吸功能和心血管发育变化的长期影响，这些变化可能对他们的成年生活产生重要的长期影响。考虑到参与研究的年轻人的独立性，我们将在位于伦敦市中心的伦敦大学学院的研究中心安排一次约会。这将使我们能够进行更好的评估，包括脑部磁共振扫描。我们将评估以下功能领域：认知，执行功能（注意力，信息处理），记忆，行为，呼吸功能和血管僵硬，以及感觉阈值。我们的MRI扫描将允许我们使用最先进的分析将结构和功能测量与这些结果联系起来。此外，我们将对每个孩子进行生活方式访谈。这些评估的重要性有几个方面：我们将在孩子们的身体表现达到顶峰时进行评估，因为他们正在向成年生活过渡，因此这是评估过早出生对生长、肺部和血管影响的最佳时机，并计算出我们在童年时期对这些方面的评估有多准确；其次，我们可以评估我们对儿童时期认知和执行能力的评估有多大的预测性，或者在青少年时期有多大程度的追赶；第三，我们可以找出哪些是成年人生活中重要的关键结果，回顾我们已经收集的早期生活措施，并提出更有针对性的干预措施，以改善年轻人的结果。

项目成果

Psychiatric disorders in individuals born very preterm / very low-birth weight: An individual participant data (IPD) meta-analysis.

• DOI: 10.1016/j.eclinm.2021.101216
• 发表时间: 2021-12
• 期刊: EClinicalMedicine
• 影响因子: 15.1
• 作者: Anderson PJ;de Miranda DM;Albuquerque MR;Indredavik MS;Evensen KAI;Van Lieshout R;Saigal S;Taylor HG;Raikkonen K;Kajantie E;Marlow N;Johnson S;Woodward LJ;Austin N;Nosarti C;Jaekel J;Wolke D;Cheong JL;Burnett A;Treyvaud K;Lee KJ;Doyle LW
• 通讯作者: Doyle LW

Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010.

• DOI: 10.1038/pr.2013.204
• 发表时间: 2013-12
• 期刊: PEDIATRIC RESEARCH
• 影响因子: 3.6
• 作者: Blencowe, Hannah;Lee, Anne C. C.;Cousens, Simon;Bahalim, Adil;Narwal, Rajesh;Zhong, Nanbert;Chous, Doris;Say, Lale;Modi, Neena;Katz, Joanne;Vos, Theo;Marlow, Neil;Lawn, Joy E.
• 通讯作者: Lawn, Joy E.

Harmonisation of assessments of attention, social, emotional, and behaviour problems using the Child Behavior Checklist and the Strengths and Difficulties Questionnaire

• DOI: 10.1002/mpr.2001
• 发表时间: 2024-01-12
• 期刊: International Journal of Methods in Psychiatric Research
• 影响因子: 3.1
• 作者: Baumann N;Anderson PJ;Johnson S;Marlow N;Wolke D;Jaekel J
• 通讯作者: Jaekel J

Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia.

• DOI: 10.3233/jad-180195
• 发表时间: 2018
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Bocchetta M;Iglesias JE;Scelsi MA;Cash DM;Cardoso MJ;Modat M;Altmann A;Ourselin S;Warren JD;Rohrer JD
• 通讯作者: Rohrer JD

Advances in Neonatal Critical Care: Pushing at the Boundaries and Connecting to Long-Term Outcomes.

新生儿重症监护的进展：突破界限并连接到长期结果。

• DOI: 10.1097/ccm.0000000000005251
• 发表时间: 2021
• 期刊: Critical care medicine
• 影响因子: 8.8
• 作者: Biban P