Psychiatric disorders in individuals born very preterm / very low-birth weight: An individual participant data (IPD) meta-analysis.
Psychiatric disorders in individuals born very preterm / very low-birth weight: An individual participant data (IPD) meta-analysis.
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DOI：
10.1016/j.eclinm.2021.101216
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发表时间：
2021-12
影响因子：
15.1
通讯作者：
Doyle LW
中科院分区：
文献类型：
--
作者：
Anderson PJ;de Miranda DM;Albuquerque MR;Indredavik MS;Evensen KAI;Van Lieshout R;Saigal S;Taylor HG;Raikkonen K;Kajantie E;Marlow N;Johnson S;Woodward LJ;Austin N;Nosarti C;Jaekel J;Wolke D;Cheong JL;Burnett A;Treyvaud K;Lee KJ;Doyle LW
关于极早产（VP; <32周）或极低出生体重（VLBW; <1500 g）幸存者的精神疾病数据很少。我们比较了VP/VLBW和足月出生、正常出生体重（足月/NBW）对照组受试者的精神病诊断率。这项个体参与者数据（IPD）荟萃分析汇总了来自成人早产国际合作组织（APIC）合格群体的数据。入选标准包括：1）VP/VLBW组（出生体重<1500 g和/或胎龄<32周），2）正常出生体重/足月出生对照组（出生体重>2499 g和/或胎龄≥37周），3）使用DSM或ICD标准进行精神病诊断的结构化测量。感兴趣的诊断是注意缺陷多动障碍（ADHD）、自闭症谱系障碍（ASD）、焦虑障碍、情绪障碍、破坏性行为障碍（DBD）、进食障碍和精神障碍。对合格研究进行了系统检索（PROSPERO注册号47555）。数据来自10项研究（1385例VP/VLBW参与者，1780例对照），使用一系列工具和方法来分配诊断。那些出生VP/VLBW的人符合ASD标准的几率高出10倍（比值比[OR] 10·6，95%置信区间[CI] 2·50，44·7），符合ADHD标准的几率高5倍（OR 5.42，95% CI 3.10，9.46），达到焦虑症标准的几率是2倍（OR 1.91，95%CI 1.36，2.69），和1.5倍的几率符合标准的情绪障碍（OR 1.51，95%CI 1.08，2.12）比对照组。这种发现模式在年龄（<18岁vs. ≥18岁）和性别亚组中一致。我们的数据表明，出生VP/VLBW的个体在儿童期和成年期符合某些精神疾病标准的几率可能高于足月儿/NBW对照组。需要进一步的研究来证实我们的研究结果，并确定与出生VP/VLBW个体的精神障碍相关的因素。澳大利亚国家健康与医学研究理事会（Coordenação de Pessoal deNível上级）-国际合作一般方案;加拿大卫生研究所研究小组赠款;国家科学和技术发展理事会;芬兰科学院; Sigrid Juselius基金会; Signe和Ane Gyllenberg基金会;欧洲联盟地平线2020研究和创新方案：RECAP项目-早产儿;欧洲联盟委员会生命过程中不平等的动态：结构和过程;新西兰神经病学基金会;医学研究理事会方案赠款;新西兰卫生研究理事会;美国国家卫生研究所;挪威研究理事会;圣奥拉夫斯医院与挪威科技大学医学和健康科学学院联合研究委员会;挪威中部地区卫生局和NTNU联络委员会。
Data on psychiatric disorders in survivors born very preterm (VP; <32 weeks) or very low birthweight (VLBW; <1500 g) are sparse. We compared rates of psychiatric diagnoses between VP/VLBW and term-born, normal birthweight (term/NBW) control participants. This individual participant data (IPD) meta-analysis pooled data from eligible groups in the Adults born Preterm International Collaboration (APIC). Inclusion criteria included: 1) VP/VLBW group (birth weight <1500 g and/or gestational age <32 weeks), 2) normal birth weight/term-born control group (birth weight >2499 g and/or gestational age ≥37 weeks), and 3) structured measure of psychiatric diagnoses using DSM or ICD criteria. Diagnoses of interest were Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Anxiety Disorder, Mood Disorder, Disruptive Behaviour Disorder (DBD), Eating Disorder, and Psychotic Disorder. A systematic search for eligible studies was conducted (PROSPERO Registration Number 47555). Data were obtained from 10 studies (1385 VP/VLBW participants, 1780 controls), using a range of instruments and approaches to assigning diagnoses. Those born VP/VLBW had ten times higher odds of meeting criteria for ASD (odds ratio [OR] 10·6, 95% confidence interval [CI] 2·50, 44·7), five times higher odds of meeting criteria for ADHD (OR 5·42, 95% CI 3·10, 9·46), twice the odds of meeting criteria for Anxiety Disorder (OR 1·91, 95% CI 1·36, 2·69), and 1·5 times the odds of meeting criteria for Mood Disorder (OR 1·51, 95% CI 1·08, 2·12) than controls. This pattern of findings was consistent within age (<18 years vs. ≥18 years) and sex subgroups. Our data suggests that individuals born VP/VLBW might have higher odds of meeting criteria for certain psychiatric disorders through childhood and into adulthood than term/NBW controls. Further research is needed to corroborate our results and identify factors associated with psychiatric disorders in individuals born VP/VLBW. Australia's National Health & Medical Research Council; CAPES (Coordenação de Aperfeiçoamento de Pessoal deNível Superior) - International Cooperation General Program; Canadian Institutes of Health Research Team Grant; National Council for Scientific and Technological Development (CNPq); Academy of Finland; Sigrid Juselius Foundation; Signe and Ane Gyllenberg Foundation; European Union's Horizon 2020 research and innovation programme: Project RECAP-Preterm; European Commission Dynamics of Inequality Across the Life-course: structures and processes (DIAL); Neurologic Foundation of New Zealand; MRC programme grant; Health Research Council of New Zealand; National Institutes of Health, USA; The Research Council of Norway; Joint Research Committee between St. Olavs Hospital and Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU); Liaison Committee between Central Norway Regional Health Authority and NTNU.
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