MICA: Centre for the Improvement of Population Health through E-health Research (CIPHER)

MICA：通过电子健康研究改善人口健康中心 (CIPHER)

• 批准号: MR/K006525/1
• 负责人: Ronan Lyons
• 金额: $ 557.24万
• 依托单位: Swansea University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK006525%2F1
• 关键词: MICA; Centre; Improvement; Population; Health

The aim of the Centre for Improving Population Health through E-Health Research (CIPHER) is to carry out research that will improve the health of the nation. It will do this by developing new methods to anonymise, link and analyse healthcare and similar data, to answer a wide range of important research questions. We will often work with researchers who have established large cohort studies, helping them make their cohorts more powerful, longer lasting, and cheaper to operate. E-health research is a new field and so CIPHER will be focussing on training researchers in how to use these data and methods. CIPHER has four core research programmes: The first focuses on developing robust new methods to allow health and other information to be anonymised and analysed. For example, developing ways in which researchers accessing data cannot possibly identify the individuals involved, thereby ensuring that privacy is protected. CIPHER's other three research programmes focus on the impact on people's lives of (1) injury and the built environment; (2) mental health and substance use; and (3) infection. CIPHER researchers will undertake a range of studies to provide better insight into the causes of disease and injury, the consequences of these conditions on individuals and the population, and evaluations of treatments and policies which are designed to improve health. Knowledge of the longer term individual and societal impact of many conditions and treatments is currently very limited, as long term studies are very expensive. CIPHER's work will enable the long term follow up of outcomes using anonymised data, answering these questions effectively but at far less cost. Within its research programmes CIPHER will address many scientific questions, including: How effective are fall-prevention initiatives for older people? What is the impact of giving Vitamin D supplements to people in care homes in reducing hip fractures? Can linked data be used to help Fire and Rescue services prevent more home fires? Have interventions to make homes warmer reduced the number of deaths in winter? How much does substance use in young adults contribute to mental health problems? Does opiate substitution therapy in prison reduce the risk of death following prison release? Can linked routine data be used to identify opportunities to intervene in pathways to harm for people who self-harm or die by suicide? How can information be better used to reduce antibiotic resistant infections? Are the different micro-organisms we carry in our bowels involved in the development of serious health conditions?CIPHER will work with the NHS to develop better ways to measure patients' experiences and treatment outcomes. CIPHER will also develop methods to enable linkage of anonymised treatment data to important social outcomes such as staying in work, continuing in education, or being able to live independently at home. Such information will help the NHS design its services to meet a broader range of patients' needs. CIPHER's believes it is important to communicate effectively with patients, patient groups and the public at large about its research. A significant part of our work therefore will be setting up ways to aid this communication. We will have public representatives involved in our research throughout and they will help guide us and help us communicate effectively with wider groups. CIPHER will be one of a small number of similar Centres that is being set up in the UK and we will be working together to train researchers in these new methods and making sure universities have suitable jobs for them. CIPHER aims to be an internationally recognised centre of expertise in the use of electronic health and associated records for research and, along with other network members, position the UK as the world leader in the field, improving the population's health, increasing UK research income, and improving the economy.

通过电子健康研究改善人口健康中心（CIPHER）的目标是开展有助于改善国民健康的研究。它将通过开发新的方法来匿名化、链接和分析医疗保健和类似的数据，以回答广泛的重要研究问题。我们经常与已经建立了大型队列研究的研究人员合作，帮助他们使他们的队列更强大，更持久，更便宜。电子卫生研究是一个新领域，因此CIPHER将重点培训研究人员如何使用这些数据和方法。CIPHER有四个核心研究方案：第一个侧重于开发强有力的新方法，使健康和其他信息能够匿名和分析。例如，开发研究人员访问数据的方法不可能识别涉及的个人，从而确保隐私得到保护。CIPHER的其他三个研究项目侧重于(1)伤害和建筑环境对人们生活的影响；(2)精神健康和药物使用；(3)感染。该研究所的研究人员将进行一系列研究，以便更好地了解疾病和伤害的原因、这些情况对个人和人口的影响，以及评价旨在改善健康的治疗和政策。由于长期研究非常昂贵，目前对许多疾病和治疗对个人和社会的长期影响的了解非常有限。CIPHER的工作将能够使用匿名数据对结果进行长期跟踪，有效地回答这些问题，但成本要低得多。在其研究项目中，CIPHER将解决许多科学问题，包括：预防老年人跌倒的举措有多有效？给养老院的人补充维生素D对减少髋部骨折有什么影响？链接数据可以用来帮助消防和救援服务防止更多的家庭火灾吗？使家庭变暖的干预措施是否减少了冬季的死亡人数？年轻人使用药物对心理健康问题的影响有多大？监狱中的阿片替代疗法是否能降低出狱后的死亡风险？是否可以使用相关的常规数据来确定干预那些自残或自杀的人的伤害途径的机会？如何更好地利用信息来减少抗生素耐药感染？我们肠道中携带的不同微生物是否与严重健康状况的发展有关？CIPHER将与NHS合作开发更好的方法来衡量患者的经历和治疗结果。CIPHER还将开发方法，将匿名治疗数据与重要的社会结果联系起来，如继续工作、继续接受教育或能够在家中独立生活。这些信息将有助于NHS设计其服务，以满足更广泛的患者需求。CIPHER认为，与患者、患者群体和公众就其研究进行有效沟通是很重要的。因此，我们工作的一个重要部分将是建立帮助这种交流的方法。我们将让公众代表全程参与我们的研究，他们将帮助指导我们，帮助我们与更广泛的群体进行有效的沟通。CIPHER将是英国正在建立的少数类似中心之一，我们将共同努力培训这些新方法的研究人员，并确保大学为他们提供合适的工作。CIPHER的目标是成为国际公认的电子健康和相关记录研究的专业中心，并与其他网络成员一起，将英国定位为该领域的世界领导者，改善人口的健康，增加英国的研究收入，并改善经济。

项目成果

Incidence and antibiotic prescribing for clinically diagnosed urinary tract infection in older adults in UK primary care, 2004-2014.

• DOI: 10.1371/journal.pone.0190521
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ahmed H;Farewell D;Jones HM;Francis NA;Paranjothy S;Butler CC
• 通讯作者: Butler CC

Risk of adverse outcomes following urinary tract infection in older people with renal impairment: Retrospective cohort study using linked health record data.

• DOI: 10.1371/journal.pmed.1002652
• 发表时间: 2018-09
• 期刊: PLoS medicine
• 影响因子: 15.8
• 作者: Ahmed H;Farewell D;Francis NA;Paranjothy S;Butler CC
• 通讯作者: Butler CC

Long-term antibiotics for prevention of recurrent urinary tract infection in older adults: systematic review and meta-analysis of randomised trials.

• DOI: 10.1136/bmjopen-2016-015233
• 发表时间: 2017-05-29
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Ahmed H;Davies F;Francis N;Farewell D;Butler C;Paranjothy S
• 通讯作者: Paranjothy S

The ELAStiC (Electronic Longitudinal Alcohol Study in Communities) project IJPDS (2017) Issue 1, Vol 1:264 Proceedings of the IPDLN Conference (August 2016)

ELAStiC（社区电子纵向酒精研究）项目 IJPDS (2017) 第 1 期，第 1 卷：264 IPDLN 会议记录（2016 年 8 月）

• DOI: 10.23889/ijpds.v1i1.284
• 发表时间: 2017
• 期刊: International Journal of Population Data Science
• 作者: Akbari A

Consensus Statement on Public Involvement and Engagement with Data Intensive Health Research.

• DOI: 10.23889/ijpds.v4i1.586
• 发表时间: 2019-02-12
• 期刊: International journal of population data science
• 作者: Aitken M;Tully MP;Porteous C;Denegri S;Cunningham-Burley S;Banner N;Black C;Burgess M;Cross L;van Delden JJ;Ford E;Fox S;Fitzpatrick NK;Gallacher K;Goddard C;Hassan L;Jamieson R;Jones KH;Kaarakainen M;Lugg-Widger F;McGrail K;McKenzie A;Moran R;Murtagh MJ;Oswald M;Paprica A;Perrin N;Richards EV;Rouse J;Webb J;Willison DJ
• 通讯作者: Willison DJ