DECIPHer: Centre for the Development and Evaluation of Complex Interventions for Public Health Improvement

DECIPher：改善公共卫生复杂干预措施的开发和评估中心

• 批准号: MR/K023233/1
• 负责人: Laurence Moore
• 金额: $ 374.77万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK023233%2F1
• 关键词: DECIPHer; Centre; Development; Evaluation; Complex

To develop effective interventions to improve population health requires an understanding of what works, for whom, under what circumstances and why? This necessitates the development of epidemiologically and social scientifically informed complex and multi-factorial interventions that are effective across settings and behaviours; the rigorous evaluation of complex interventions, often using pragmatic controlled trial designs with nested process evaluation and including natural experiments of new policy programmes and the use of routine data to develop and target interventions and to provide sources of data on contexts and long term outcomes for intervention studies. The centre for the Development and Evaluation of Complex Interventions for Public Health Improvement (DECIPHer) brings together a team of world class researchers with expertise in a wide variety of quantitative and qualitative evaluation methods and intervention technologies to address these issues. Building on a strong track record in working with partners from public health policy and practice, and in public involvement in research, we will develop, test, evaluate and then implement interventions that are effective in improving the health of the population across settings and behaviours and which address health inequalities, with a particular focus on children and young people. DECIPHer's aims are to conduct research that:1. will lead to measurable improvements in the health of children and young people2. identifies policies and interventions that are readily adopted, implemented and maintained in the real world and are effective in improving health and reducing health inequalities.We will also provide high quality training programmes to develop the skills and careers of public health researchers, and a focal point for collaboration with policy and practice. For its second five-year period of funding, DECIPHer's core Centre resources will be focussed on developing a high quality cadre of early career researchers who, with a multidisciplinary team of senior scientists will take forward four research programmes:The first will examine multiple risk behaviours in young people and their antecedents to develop complex interventions which address multiple risk behaviours and their causes. The second will develop and conduct a programme of research on organisational approaches to promoting health in schools and other youth settings. The third will focus on further development of methods to develop and evaluate complex interventions, with an emphasis on applying randomised trials and other high quality research designs to evaluating interventions in a way that produces rigorous evidence that is useful to public health decision makers. The fourth programme is also methodological in nature, and is concerned with maximising the use of routine data from population surveys and other administrative sources to improve our understanding of the determinants of population health and facilitate the evaluation of interventions without the need for expensive collection of new data. These four complementary programmes will provide a platform for multiple applied research projects, funded through additional competitive grant funding, which will be strategically co-ordinated within and across three broad priority areas relating to the health of children and young people: Tobacco, Alcohol, Drugs; Obesity, Physical activity, Diet; Mental health and wellbeing. DECIPHer will address health behaviour in its widest sense, encompassing individual risk and protective behaviour and the contexts and structures that improve, sustain or undermine health and well-being. Adopting a socio ecological approach, the focus will be on multiple behaviours and on the design and evaluation of interventions that take full account of the interdependencies between individual, social, family, community, organisational and policy factors.

为了制定有效的干预措施以改善人口健康，需要了解什么对谁有效，在什么情况下有效，为什么？这就需要制定具有流行病学和社会科学知识的复杂和多因素干预措施，这些干预措施在各种环境和行为中都是有效的；对复杂干预措施进行严格的评估，通常使用具有嵌套过程评估的务实对照试验设计，包括新政策方案的自然实验，并使用常规数据来制定干预措施和确定干预措施的目标，并为干预研究提供关于背景和长期结果的数据来源。改善公共卫生的复杂干预措施发展和评价中心汇集了一支世界级的研究人员团队，他们在各种定量和定性评估方法和干预技术方面具有专业知识，以解决这些问题。我们将在与公共卫生政策和实践的伙伴合作以及公众参与研究方面的良好记录的基础上，制定、测试、评估和实施干预措施，这些干预措施有效地改善不同环境和行为的人口的健康，并解决健康不平等问题，特别注重儿童和年轻人。Decpher的目标是进行研究，以：1。将导致儿童和年轻人健康的可衡量的改善2。确定在现实世界中容易被采纳、实施和维持的、在改善健康和减少健康不平等方面有效的政策和干预措施。我们还将提供高质量的培训计划，以发展公共卫生研究人员的技能和职业生涯，并成为与政策和实践合作的中心。在第二个五年的资助期内，Decpher中心的核心资源将集中于培养一支高素质的早期职业研究人员队伍，他们将与一个由资深科学家组成的多学科团队一起推进四个研究方案：第一个方案将审查年轻人及其前驱的多种危险行为，以制定针对多种危险行为及其原因的复杂干预措施。第二个项目将制定和开展一项关于在学校和其他青年环境中促进健康的组织方法的研究方案。第三个重点是进一步开发开发和评估复杂干预措施的方法，重点是应用随机试验和其他高质量的研究设计，以产生对公共卫生决策者有用的严格证据的方式评估干预措施。第四个方案也是方法性的，涉及最大限度地利用来自人口调查和其他行政来源的常规数据，以增进我们对人口健康决定因素的了解，并促进对干预措施的评估，而不需要昂贵的新数据收集。这四个相辅相成的方案将为多个应用研究项目提供平台，这些项目通过额外的竞争性赠款资金提供资金，这些项目将在与儿童和青年健康有关的三个广泛优先领域内和跨三个领域进行战略协调：烟草、酒精、毒品；肥胖、体力活动、饮食；心理健康和福祉。《破译》将在最广泛的意义上处理健康行为，包括个人风险和保护性行为，以及改善、维持或破坏健康和福祉的背景和结构。采用社会生态学方法，重点将放在多种行为上，并注重设计和评价干预措施，充分考虑到个人、社会、家庭、社区、组织和政策因素之间的相互依存关系。

项目成果

The Children of Looked After Children - Outcomes, Experiences and Ensuring Meaningful Support to Young Parents In and Leaving Care

被照顾儿童的孩子 - 结果、经验以及确保为年轻父母提供有意义的支持和离开照顾

• DOI: 10.2307/j.ctv1jbzchd.7
• 发表时间: 2021
• 作者: Anthony R

Adversity profiles of children receiving care and support from social services: A latent-class analysis of school-aged children in Wales

接受社会服务照顾和支持的儿童的逆境概况：威尔士学龄儿童的潜在阶层分析

• DOI: 10.1111/cch.13097
• 发表时间: 2023
• 期刊: Care, Health and Development
• 作者: Anthony R

Energy Drink Mechanisms of Harm in Young People and Adolescents: A Narrative Review

能量饮料对年轻人和青少年的危害机制：叙述回顾

• 发表时间: 2020
• 期刊: Journal of Food and Nutrition Research
• 影响因子: 1.1
• 作者: Alhumud M

Do patient access schemes for high-cost cancer drugs deliver value to society?-lessons from the NHS Cancer Drugs Fund.

• DOI: 10.1093/annonc/mdx110
• 发表时间: 2017-08-01
• 期刊: Annals of oncology : official journal of the European Society for Medical Oncology
• 作者: Aggarwal A;Fojo T;Chamberlain C;Davis C;Sullivan R
• 通讯作者: Sullivan R

Long-term effects of the Active for Life Year 5 (AFLY5) school-based cluster-randomised controlled trial.

• DOI: 10.1136/bmjopen-2015-010957
• 发表时间: 2016-11-24
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Anderson EL;Howe LD;Kipping RR;Campbell R;Jago R;Noble SM;Wells S;Chittleborough C;Peters TJ;Lawlor DA
• 通讯作者: Lawlor DA