Determining the role of macrophages and ageing in involution-associated mammary tumourigenesis

确定巨噬细胞和衰老在退化相关乳腺肿瘤发生中的作用

• 批准号: MR/K011014/1
• 负责人: Christine Watson
• 金额: $ 41.97万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK011014%2F1
• 关键词: Determining; role; macrophages; ageing; involution

Breast cancer already affects 1 in 8 women in the UK and the incidence of breast cancer is on the increase. Following lactation, the breast undergoes a dramatic remodelling process called involution that induces the death of the milk-producing cells. These dead cells are then removed by a specific type of immune cell called a macrophage. We have shown that macrophages are affected by a factor called Stat3 which is activated during the involution process. Our aim in this project is to investigate the role of macrophages in promoting tumour growth during involution. We also wish to understand the effects of age on both involution and involution-associated cancer development. This work will result in increased understanding of the causes of breast cancer spread during involution and how this is influenced by macrophages. In addition, we hope that we will be able to derive a set of marker genes that are associated with changes in the breasts of older women that predispose them to higher risk of breast cancer.

在英国，乳腺癌已经影响到八分之一的妇女，而且乳腺癌的发病率正在上升。哺乳后，乳房经历了一个戏剧性的重塑过程，称为退化，导致产奶细胞死亡。这些死细胞然后被称为巨噬细胞的特定类型的免疫细胞清除。我们已经表明，巨噬细胞受到一种名为Stat3的因子的影响，该因子在退化过程中被激活。我们在这个项目中的目的是研究巨噬细胞在促进肿瘤生长过程中的作用。我们还希望了解年龄对退化和退化相关癌症发展的影响。这项工作将导致对退化期间乳腺癌扩散的原因以及巨噬细胞如何影响的更多了解。此外，我们希望我们将能够获得一组标记基因，这些基因与老年妇女乳房的变化有关，这些变化使她们更容易患乳腺癌。

项目成果

Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue.

• DOI: 10.1038/cddis.2016.302
• 发表时间: 2016-10-06
• 期刊: Cell death & disease
• 影响因子: 9
• 作者: Hughes K;Blanck M;Pensa S;Watson CJ
• 通讯作者: Watson CJ

Anti-CCL2: building a reservoir or opening the floodgates to metastasis?

• DOI: 10.1186/s13058-015-0573-4
• 发表时间: 2015-05-21
• 期刊: Breast cancer research : BCR
• 作者: Hitchcock JR;Watson CJ
• 通讯作者: Watson CJ

Development of three-dimensional collagen scaffolds with controlled architecture for cell migration studies using breast cancer cell lines

开发具有受控结构的三维胶原蛋白支架，用于使用乳腺癌细胞系进行细胞迁移研究

• DOI: 10.17863/cam.7262
• 发表时间: 2017
• 作者: Campbell J

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

• DOI: 10.1186/bcr3493
• 发表时间: 2013-10-01
• 期刊: Breast cancer research : BCR
• 作者: Eccles SA;Aboagye EO;Ali S;Anderson AS;Armes J;Berditchevski F;Blaydes JP;Brennan K;Brown NJ;Bryant HE;Bundred NJ;Burchell JM;Campbell AM;Carroll JS;Clarke RB;Coles CE;Cook GJ;Cox A;Curtin NJ;Dekker LV;Silva Idos S;Duffy SW;Easton DF;Eccles DM;Edwards DR;Edwards J;Evans D;Fenlon DF;Flanagan JM;Foster C;Gallagher WM;Garcia-Closas M;Gee JM;Gescher AJ;Goh V;Groves AM;Harvey AJ;Harvie M;Hennessy BT;Hiscox S;Holen I;Howell SJ;Howell A;Hubbard G;Hulbert-Williams N;Hunter MS;Jasani B;Jones LJ;Key TJ;Kirwan CC;Kong A;Kunkler IH;Langdon SP;Leach MO;Mann DJ;Marshall JF;Martin L;Martin SG;Macdougall JE;Miles DW;Miller WR;Morris JR;Moss SM;Mullan P;Natrajan R;O'Connor JP;O'Connor R;Palmieri C;Pharoah PD;Rakha EA;Reed E;Robinson SP;Sahai E;Saxton JM;Schmid P;Smalley MJ;Speirs V;Stein R;Stingl J;Streuli CH;Tutt AN;Velikova G;Walker RA;Watson CJ;Williams KJ;Young LS;Thompson AM
• 通讯作者: Thompson AM

Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue

Stat3 调节正常和肿瘤乳腺组织中氯离子通道辅助蛋白的表达

• DOI: 10.17863/cam.10161
• 发表时间: 2016
• 作者: Hughes K