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Developing and refining methods of analysing malaria genetic data obtained from infected human blood samples.

开发和完善分析从受感染的人类血液样本中获得的疟疾遗传数据的方法。

基本信息

批准号：
MR/K014676/1
负责人：
Ian Hastings
金额：
$ 44.24万
依托单位：
Liverpool School of Tropical Medicine
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FK014676%2F1
关键词：
Developing refining methods analysing malaria

项目摘要

The spread of drug resistant malaria is a potent threat to human health in much of the developing world. Resistance can be tracked and quantified provided we know the mutations responsible for resistance (true in many cases) and these data form the basis for many key genetic surveillance programmes aimed at ensuring the continued provision of effective drugs. The requisite malaria genetic data can, in principle, be obtained from analysing infected human blood samples but people are often simultaneously infected by several malaria clones and this makes it impossible to clearly identify the genetic composition of any single clone. We propose a program of research to develop and refine suitable methodologies that can overcome these problems of data interpretation allowing good quality genetic data on the frequency of drug resistance to inform public health policy. These methods of analysis also have more general application in understanding the genetic epidemiology of malaria transmission.

在许多发展中国家，抗药性疟疾的传播是对人类健康的一大威胁。只要我们知道导致耐药性的突变(在许多情况下是正确的)，就可以对耐药性进行跟踪和量化，这些数据构成了许多旨在确保继续提供有效药物的关键遗传监测方案的基础。原则上，必要的疟疾遗传数据可以通过分析受感染的人类血液样本获得，但人们往往同时感染几个疟疾克隆，这使得无法清楚地确定任何单个克隆的基因构成。我们提出了一项研究计划，以开发和改进适当的方法，以克服数据解释的这些问题，允许高质量的耐药频率基因数据为公共卫生政策提供信息。这些分析方法在了解疟疾传播的遗传流行病学方面也有更广泛的应用。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Incidence and Differential Seasonal Patterns of Plasmodium vivax Primary Infections and Relapses in a Cohort of Children in Papua New Guinea.

DOI：
10.1371/journal.pntd.0004582
发表时间：
2016-05
期刊：
PLoS neglected tropical diseases
影响因子：
3.8
作者：
Ross A;Koepfli C;Schoepflin S;Timinao L;Siba P;Smith T;Mueller I;Felger I;Tanner M
通讯作者：
Tanner M

The incidence and differential seasonal patterns of Plasmodium vivax primary infections and relapses in a cohort of children in Papua New Guinea

巴布亚新几内亚一组儿童间日疟原发感染和复发的发病率和不同季节模式