Determining shared genetic control of RNA transcription across 45 human tissue types

确定 45 种人体组织类型中 RNA 转录的共享遗传控制

• 批准号: nhmrc : 1083405
• 金额: $ 17.65万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-shared-genetic-tissue-types/518931
• 关键词: Determining; shared; genetic; control; RNA

There is strong evidence that much of the genetic susceptibility to disease acts through altering way genes are turned into proteins via RNA transcripts. One important problem in using transcriptomic data to study diseases is that the genetic control of RNA transcription is known to vary between tissues. This study will use new methods and RNA data from 45 human tissues to show the degree of common genetic control for each RNA transcript between each pair of tissues.

有强有力的证据表明，对疾病的遗传易感性大部分是通过改变基因通过RNA转录物转化为蛋白质的方式而起作用的。使用转录组学数据研究疾病的一个重要问题是已知RNA转录的遗传控制在组织之间是不同的。这项研究将使用新的方法和来自45个人体组织的RNA数据来显示每对组织之间每个RNA转录物的共同遗传控制程度。