Patient oriented research and mentoring program in dermatologic diseases

以患者为中心的皮肤病研究和指导计划

• 批准号: 10685455
• 负责人: MARYAM Mandana ASGARI
• 金额: $ 19.24万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-02 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10685455
• 关键词: Address; Applications Grants; Award; Carcinoma; Clinical; Clinical Investigator; Cutaneous; DNA; Data; Data Set; Dermatologic; Dermatology; Development; Development Plans; Diagnostic; Disease; Disease Progression; Educational Status; Environment; Environmental Risk Factor; Epidemiology; Epigenetic Process; Faculty; Feedback; Foundations; Funding; Gene Combinations; Gene Expression; General Hospitals; Genetic; Genotype; Genotype-Tissue Expression Project; Goals; Growth; Individual; Institution; Investments; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Learning; Massachusetts; Measurement; Medical Students; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Modification; Mohs Surgery; Molecular; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Outcome; Parents; Pathology; Patient Self-Report; Patients; Peer Review; Peer Review Grants; Physicians; Play; Population; Positioning Attribute; Postdoctoral Fellow; Principal Investigator; Productivity; Publications; Research; Research Activity; Research Assistant; Research Personnel; Research Project Grants; Research Support; Residencies; Risk; Role; Scientist; Skin Cancer; Structure; Surgeon; Time; Tissues; Training; Training and Education; United States National Institutes of Health; Work; cancer care; cancer initiation; carcinogenesis; care delivery; career; career development; catalyst; dietary supplements; disease prognostic; disorder risk; epigenomics; experience; gene function; genome-wide; innovation; insight; keratinocyte; medical schools; novel; patient engagement; patient oriented; patient oriented research; professor; prognostic indicator; programs; public health relevance; research study; secondary analysis; shared decision making; skills; skin disorder; skin organogenesis; synergism; tool; training opportunity; tumorigenesis

Abstract The overall goals of this K24 renewal application are to continue to provide Maryam Asgari MD, MPH with protected time to serve as a mentor to junior clinical investigators, and to support new scientific aims that will build upon Dr. Asgari's established work on patient-oriented research in skin diseases. Dr. Asgari is a nationally recognized dermatoepidemiologist and Mohs surgeon and the Director of the Patient-Oriented Research in the Epidemiology of Skin Diseases (PORES) unit at Harvard Medical School. She is the principal investigator of several large patient-oriented research studies, including two NIH-funded R01s examining genetic and environmental factors impacting the development of skin cancer. The parent K24 award has allowed Dr. Asgari the protected time to successfully mentor over 30 trainees ranging from medical students to junior faculty. This K24 renewal award would allow her to 1) continue mentoring junior investigators, particularly NIH K23 awardees, 2) pursue new research in cutaneous carcinogenesis with a renewed focus on epigenomic changes in carcinogenesis and the role of dietary supplements in keratinocyte carcinoma risk, and 3) establish a new research direction focused on shared decision making in skin cancer care. The research plan (Aim 1) builds on an ongoing NIAMS- and NCI-funded portfolio of projects led by Dr. Asgari. The proposed new aims will take advantage of existing data from these R01 awards and allow mentees the ability to use existing datasets to examine novel topics in keratinocyte carcinogenesis. This renewal will be an important catalyst for Dr. Asgari’s professional growth by enabling her to learn and conduct innovative patient-facing research involving shared decision making in keratinocyte carcinoma management. The mentoring plan (Aim 2) in this continuation period will allow for the implementation of a structured mentoring program tailored at the individual level to engage mentees using a formal individual development plan. Mentoring outcomes will be assessed using a validated tool for anonymous feedback from mentees, and mentoring skills will be refined by utilizing a mentoring coach. Dr. Asgari will continue her successful trajectory of providing direct mentorship to dermatology residents, research fellows, and junior faculty at her institution. Her plan for the next 5 years is to leverage her efforts for career development of patient-oriented researchers at the national level. This K24 renewal will be an important catalyst for Dr. Asgari’s professional growth by enabling her to conduct innovative research and mentor new investigators on performing patient-oriented dermatologic research. The mentoring and research activities in this plan will open new opportunities for a long-term professional trajectory that would not be attainable without a renewal period. By supporting Dr. Asgari’s efforts in mentoring, the award is an excellent investment in the junior investigators at her institution.

摘要 此K24更新申请的总体目标是继续为Maryam Asgari MD，MPH提供 保护时间，作为初级临床研究者的导师，并支持新的科学目标， 建立在Asgari博士在皮肤病患者导向研究方面的既定工作基础上。Asgari博士是一位 全国公认的皮肤流行病学家和莫氏外科医生和主任的病人为导向的 哈佛医学院皮肤病流行病学（PORES）研究。她是校长 几项大型以患者为导向的研究的研究者，包括两项NIH资助的R 01研究 影响皮肤癌发展的遗传和环境因素。K24大奖 让Asgari博士有受保护的时间成功地指导了30多名学员，从医学生到 初级教员。这个K24续约奖将允许她1）继续指导初级调查员， 特别是NIH K23获奖者，2）继续进行皮肤癌发生的新研究，重新关注 致癌作用中的表观基因组变化和膳食补充剂在角化细胞癌风险中的作用，以及 3)建立一个新的研究方向，专注于皮肤癌护理的共同决策。 该研究计划（目标1）建立在一个正在进行的NIAMS和NCI资助的项目组合，由博士领导。 阿斯加里拟议的新目标将利用这些R01奖项的现有数据， 使用现有数据集来研究角质形成细胞癌变过程中的新主题的能力。此次续约将是 Asgari博士的专业成长的重要催化剂，使她能够学习和进行创新 面向患者的研究，涉及角质形成细胞癌管理中的共同决策。 本延续期的辅导计划（目标2）将允许实施结构化的 针对个人层面量身定制的辅导计划，通过正式的个人发展吸引学员 计划将使用经过验证的工具评估辅导成果，以获得受辅导者的匿名反馈，以及 将利用辅导教练改进辅导技能。阿斯加里博士将继续她的成功轨迹 为她所在机构的皮肤科住院医师、研究员和初级教员提供直接指导。 她未来5年的计划是利用她的努力，为面向患者的研究人员的职业发展 在国家层面 此次K24续约将成为Asgari博士专业成长的重要催化剂，使她能够 进行创新研究，指导新的研究人员进行以患者为导向的皮肤病学 research.该计划中的指导和研究活动将为长期的研究提供新的机会。 职业轨迹，没有一个更新期是无法实现的。通过支持阿斯加里博士的努力 在指导方面，该奖项是对她所在机构的初级调查员的一项极好的投资。

项目成果

Relationship between body mass index and atopic dermatitis: a Mendelian randomization approach in exploring causality: a critical appraisal.

• DOI: 10.1111/bjd.19702
• 发表时间: 2021-06
• 期刊: The British journal of dermatology
• 作者: Pan CX;Jee YH;Moore KJ;Kraft P;Asgari MM
• 通讯作者: Asgari MM

Patterns of Tumor-Infiltrating Lymphocytes Used to Distinguish Primary Cutaneous Squamous Cell Carcinomas That Metastasize.

• DOI: 10.1001/jamadermatol.2023.1307
• 发表时间: 2023-05
• 期刊: JAMA dermatology
• 影响因子: 10.9
• 作者: S. Ashrafzadeh;R. Foreman;Sara Kalra;A. Mandinova;M. Asgari

Research Techniques Made Simple: Interpreting Measures of Association in Clinical Research.

研究技术变得简单：解释临床研究中的关联测量。

• DOI: 10.1016/j.jid.2018.12.023
• 发表时间: 2019
• 期刊: The Journal of investigative dermatology
• 作者: Roberts,MichelleR;Ashrafzadeh,Sepideh;Asgari,MaryamM
• 通讯作者: Asgari,MaryamM

Community-Based Practice Variations in Topical Treatment of Actinic Keratoses.

基于社区的光化性角化病局部治疗的实践变化。

• DOI: 10.1001/jamadermatol.2016.6251
• 发表时间: 2017
• 期刊: JAMA dermatology
• 影响因子: 10.9
• 作者: Storer,Molly;Zhu,Zheng;Sokil,Monika;Ford,Margaret;Neugebauer,Romain;Asgari,MaryamM
• 通讯作者: Asgari,MaryamM

Association between Human Leukocyte Antigen Type and Keratinocyte Carcinoma Risk in Renal Transplant Recipients.

• DOI: 10.1016/j.jid.2019.09.016
• 发表时间: 2020-05
• 期刊: The Journal of investigative dermatology
• 作者: Kim Y;Wojciechowski D;Pattanayak V;Lee H;Asgari MM
• 通讯作者: Asgari MM