Determining the tumour suppressor function of the MCC gene and its significance to treatment outcomes in colorectal cancer.

该项目分析了肠癌的早期阶段，我们发现了一种新的基因缺陷。我们希望通过研究一种新的肠癌小鼠模型来确定MCC基因缺陷如何促进肿瘤发生以及它如何影响治疗结果。这将确定在肠肿瘤中MCC丧失后哪些细胞功能发生改变，以及MCC缺陷是否可以用于识别将从放射治疗或特定化疗中受益的患者。

This project analyses the early stages of bowel cancer, where we have discovered a new gene defect. We want to determine how the MCC gene defect promotes tumorigenesis and how it affects treatment outcomes, by studying a novel mouse model of bowel cancer. This will determine which cellular functions are altered following loss of MCC in bowel tumours and if the MCC defect can be exploited to identify patients who would benefit from radiotherapy or specific chemotherapies.