Automated delivery of high-viability therapeutic cell populations following revival from cryopreservation

点击翻译按钮获取中文摘要

The project aims to develop a commercial demonstrator instrument - the ReVive Controlled Thaw device (ReVive-CT) to customers within the cell therapy sector who ship frozen product to the patient and need to ensure the highest possible viability and reproducibility of cells at the point of treatment. Combining core biological and engineering skills in order to 'pharmaceuticalise' use of cryopreserved therapeutic cells - the transition from cleanroom to clinic will be streamlined to optimise (1) ease of delivery to the patient, (2) high-viability and cell dosage (and therefore high efficacy), and (3) consistency and reproducibility of high-quality product delivered. Furthermore, it is envisaged that the system will have additional applications - eg during early-stage bioprocessing - where controlled thawing of cells from banked stocks is an important processing consideration.