CLINICAL STUDIES OF SENSORY GATING

项目1负责生理表型的临床研究。 与精神分裂症有关。心理神经科学中心的目标 精神障碍是将基础科学专业知识应用于慢性精神疾病 无序。然而，这些疾病是复杂的、多方面的综合征。 不能立即服从于基础科学研究的研究。这 项目负责确定以下项目的离散赤字 精神分裂症患者可能更直接地代表神经元功能障碍，所以 其他项目可以利用这些缺陷来研究基因和分子 研究，用于在分离组织中的研究，以及在动物身上的建模。 项目1还负责在人类受试者身上进行任何 从基础科学研究中得出的假设。两种生理学 大多数研究将使用测量方法：平滑追踪眼的缺陷 听觉诱发的P50运动和抑制门控减弱 潜在的反应。将进行三个实验：(1)联动 与项目2合作使用这些措施的研究，以及 临床诊断，以确定这些表型中的一个或多个 识别与精神分裂症传播有关的基因；(2) 研究尼古丁对测量的影响，以确定是否 尼古丁使缺陷正常化，正如项目3‘S动物所预测的那样 模型；以及(3)调查以确定因素，如增加 儿茶酚胺代谢，导致这些指标的变异性，以 提高它们在临床研究中的有用性。此外，项目1 为项目6和7收集尸检和流产的组织标本。

Project 1 is responsible for clinical studies of physiological phenotypes related to schizophrenia. The aim of Centers for Neuroscience of Mental Disorders is to bring basic science expertise to bear upon chronic mental disorder. However, these disorders are complex, multi-faceted syndromes that are not immediately amenable to basic science investigation. This project is responsible for identifying discrete deficits in schizophrenics that may more directly represent neuronal dysfunction, so that other projects can use these deficits for genetic and molecular studies, for study in isolated tissue, and for modeling in animals. Project 1 is also responsible for testing in human subjects any hypotheses reached from basic science research. Two physiological measures will be used for most studies: deficits in smooth pursuit eye movements and diminished inhibitory gating of the P50 auditory evoked potential response. Three experiments will be performed: (1) linkage studies using these measures in collaboration with Project 2, along with clinical diagnoses, to determine if one or more of these phenotypes identifies genes relevant to the transmission of schizophrenia; (2) studies of the effects of nicotine on the measures, to determine if nicotine normalizes the defects, as predicted by Project 3's animal model; and (3) investigations to define factors, such as increased catecholamine metabolism, that cause variability in these measures, to improve their usefulness for clinical research. In addition, Project 1 collects post mortem and aborted tissue specimens for Projects 6 and 7.