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PILOT TRIAL OF TC SESTAMIBI WITH CYCLOSPORINE A AND VINBLASTINE IN CANCER

PILOT TRIAL OF TC SESTAMIBI WITH CYCLOSPORINE A AND VINBLASTINE IN CANCER
TC Sestamibi 与环孢菌素 A 和长春花碱治疗癌症的试点试验
批准号：
5218376
负责人：
DAVID SMITH
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5218376
关键词：
P glycoprotein clinical research combination chemotherapy cyclosporines human subject human therapy evaluation neoplasm /cancer chemotherapy neoplasm /cancer radionuclide diagnosis pharmacokinetics radionuclide imaging /scanning radiotracer technetium vinblastine

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中文摘要
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英文摘要
This is a feasibility study using TcSESTAMIBI, a technetium labelled probe that has potential to identify p-glycoprotein pump activity. It is being evaluated as an indicator of an alteration in "in vivo" P-glycoprotein function. Cyclosporine is an inhibitor of this pump and will be tested alone and in combination with vinblastine in patients with tumors known to have increased levels of P-glycoprotein. Additionally, this study seeks to establish a method to quantify uptake of TcSESTAMIBI in tumor an normal tissues so that valid and reliable comparisons can be made.
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