PHASE I TRIAL OF SUBCUTANEOUS CALCITRIOL AND PREDNISONE IN TUMORS
PHASE I TRIAL OF SUBCUTANEOUS CALCITRIOL AND PREDNISONE IN TUMORS
批准号:
5218441
负责人:
DAVID SMITH
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
维生素D是一种类固醇激素,以其调节
钙和骨骼代谢。维生素D的活性形式是骨化三醇
[1,25-(OH)2D3]。流行病学证据表明骨化三醇可能起作用
在结肠癌和前列腺癌的发展过程中起着重要作用。
对肿瘤细胞系的临床前研究表明,骨钙素可以杀死
然而,动物研究表明,肿瘤细胞所需的剂量
也会导致高钙血症。强的松能有效地降低
高钙血症。这项研究的前提是进行第一阶段;第二阶段
降钙素与泼尼松联合用药的临床评价
晚期癌症患者。
英文摘要
Vitamin D is a steroid hormone best known for its activity in regulating
calcium and bone metabolism. The active form of vitamin D is calcitriol
[1,25-(OH)2D3]. Epidemiologic evidence suggests that calcitriol may play
an important role in the development of colon and prostate cancer.
Preclinical study of cancer cell lines have shown that calcitrol can kill
tumor cells, however, animal studies have shown that the doses required
also induce hypercalcemia. Prednisone is effective in reducing
hypercalcemia. The premise of this study is to conduct a phase I;II
study to evaluate the combined approach of calcitrol and prednisone in
patients with advanced cancer.
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会议论文
NATL HLTH ORG STRATEGIES TO PROVIDE INFO ON HEMATOLOGIC CANCERS
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批准号:7404074
-
项目类别:
-
资助金额:$27.95万
-
财政年份:2004
-
负责人:DAVID SMITH
-
依托单位:
NATL HLTH ORG STRATEGIES TO PROVIDE INFO ON HEMATOLOGIC CANCERS
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批准号:7404073
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项目类别:
-
资助金额:$27.95万
-
财政年份:2004
-
负责人:DAVID SMITH
-
依托单位:
NATL HLTH ORG STRATEGIES TO PROVIDE INFO ON HEMATOLOGIC CANCERS
-
批准号:7404075
-
项目类别:
-
资助金额:$27.95万
-
财政年份:2004
-
负责人:DAVID SMITH
-
依托单位:
PHASE II CLINICAL TRIALS OF NEW CHEMOPREVENTIVE AGENTS
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批准号:2521417
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项目类别:
-
资助金额:$0.0万
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财政年份:1995
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负责人:DAVID SMITH
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依托单位:
PHASE II CLINICAL TRIALS OF NEW CHEMOPREVENTIVE AGENTS
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批准号:2302909
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项目类别:
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资助金额:$0.0万
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财政年份:1995
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负责人:DAVID SMITH
-
依托单位:
PHASE II CLINICAL TRIALS OF NEW CHEMOPREVENTIVE AGENTS
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批准号:2422672
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项目类别:
-
资助金额:$0.0万
-
财政年份:1995
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负责人:DAVID SMITH
-
依托单位:
PHASE II CLINICAL TRIALS OF NEW CHEMOPREVENTIVE AGENTS
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批准号:2302908
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项目类别:
-
资助金额:$63.23万
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财政年份:1995
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负责人:DAVID SMITH
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依托单位:
TREATMENT & PREVENTION IN THE ERA OF SMOKEABLE DRUGS
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批准号:3060040
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项目类别:
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资助金额:$0.0万
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财政年份:1991
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负责人:DAVID SMITH
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依托单位:
PILOT TRIAL OF TC SESTAMIBI WITH CYCLOSPORINE A AND VINBLASTINE IN CANCER
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批准号:5218376
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:DAVID SMITH
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依托单位:--
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