PHASE I TRIAL OF SUBCUTANEOUS CALCITRIOL AND PREDNISONE IN TUMORS

维生素D是一种类固醇激素，以其调节 钙和骨骼代谢。维生素D的活性形式是骨化三醇 [1，25-(OH)2D3]。流行病学证据表明骨化三醇可能起作用 在结肠癌和前列腺癌的发展过程中起着重要作用。 对肿瘤细胞系的临床前研究表明，骨钙素可以杀死 然而，动物研究表明，肿瘤细胞所需的剂量 也会导致高钙血症。强的松能有效地降低 高钙血症。这项研究的前提是进行第一阶段；第二阶段 降钙素与泼尼松联合用药的临床评价 晚期癌症患者。

Vitamin D is a steroid hormone best known for its activity in regulating calcium and bone metabolism. The active form of vitamin D is calcitriol [1,25-(OH)2D3]. Epidemiologic evidence suggests that calcitriol may play an important role in the development of colon and prostate cancer. Preclinical study of cancer cell lines have shown that calcitrol can kill tumor cells, however, animal studies have shown that the doses required also induce hypercalcemia. Prednisone is effective in reducing hypercalcemia. The premise of this study is to conduct a phase I;II study to evaluate the combined approach of calcitrol and prednisone in patients with advanced cancer.