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PHASE I/II PHARMACOKINETIC STUDY OF TAXOL AND CARBOPLATIN WITH FILGRASTIM

PHASE I/II PHARMACOKINETIC STUDY OF TAXOL AND CARBOPLATIN WITH FILGRASTIM
紫杉醇和卡铂与非格司亭的 I/II 期药代动力学研究
批准号：
5218424
负责人：
CHANDRA BELANI
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5218424
关键词：
blood chemistry cis platinum compound clinical research clinical trial phase I colony stimulating factor combination chemotherapy dosage drug screening /evaluation human subject human therapy evaluation neoplasm /cancer chemotherapy neoplasm /cancer relapse /recurrence nonsmall cell lung cancer paclitaxel pharmacokinetics platinum

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中文摘要
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英文摘要
The objective of this phase I/II study is to determine the maximum tolerated dose of taxol in combination with carboplatin in previously untreated patients with advanced or recurrent Non Small Cell Lung Cancer (NSCLC); define the pharmacokinetics of carboplatin with combination therapy, and correlate 24 hour total plasma platinum concentration and pharmacodynamic consequences of therapy with the AUC of carboplatin.
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