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PHASE I PHARMACOKINETIC STUDY OF CARBOPLATIN IN COMBO WITH WEEKLY PACLITAXEL

PHASE I PHARMACOKINETIC STUDY OF CARBOPLATIN IN COMBO WITH WEEKLY PACLITAXEL
卡铂联合每周紫杉醇的 I 期药代动力学研究
批准号：
6114612
负责人：
CHANDRA BELANI
金额：
$2.9万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
项目状态：
已结题
起止时间：
1978-12-01 至 2003-11-30
来源：
https://reporter.nih.gov/project-details/6114612
关键词：
carboplatin clinical research clinical trial phase I combination chemotherapy drug administration rate /duration drug adverse effect drug interactions drug screening /evaluation human subject human therapy evaluation neoplasm /cancer chemotherapy paclitaxel pharmacokinetics

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中文摘要
翻译
一项I期研究，研究者计划将联合收割机卡铂 每3周给药一次，每周一次紫杉醇。的剂量强度 紫杉醇可以通过每周给药显著增加， 最小的血液学毒性，此外，紫杉醇还可能具有 对卡铂诱导的血小板减少症有保护作用。我们提前 在这种组合中增加的紫杉醇剂量强度将 导致开发出一种没有增加毒性的活性方案， 每三周一次的固定时间表。
英文摘要
A Phase I study in which the investigators plan to combine carboplatin given every 3 weeks with weekly paclitaxel. The dose intensity of paclitaxel can be increased considerably by weekly administration with minimal hematological toxicity and in addition, paclitaxel may also have a protective effect on carboplatin induced thrombocytopenia. We anticpate that the increased dose intensity of paclitaxel in this combination would result in developing an active regimen without added toxicity as seen on a regular every 3-week schedule.
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