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FILGRASTIM SD/01 PTS W/ NON SMALL CELL LUNG CANCER OR THORACIC TUMORS

FILGRASTIM SD/01 PTS W/ NON SMALL CELL LUNG CANCER OR THORACIC TUMORS
FILGRASTIM SD/01 PTS 治疗非小细胞肺癌或胸部肿瘤
批准号：
6264156
负责人：
CHANDRA BELANI
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264156
关键词：
cis platinum compound clinical research clinical trial phase I colony stimulating factor drug interactions drug screening /evaluation hematopoietic stem cells human subject human therapy evaluation neoplasm /cancer chemotherapy neoplasm /cancer immunotherapy neutrophil nonsmall cell lung cancer paclitaxel pharmacokinetics thorax neoplasm

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中文摘要
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英文摘要
The specific aims of this study are to compare the safety of Filgrastim-SD/01 to Filgrastim administered to non-small cell lung cancer patients in hematologic steady state; and to compare the pharmacokinetics (PK) of Filgrastim-SD/01 to Filgrastim pre-chemotherapy; and to compare the pharmacodynamic (PD) responses to Filgrastim-SD/01 to Filgrastim as measured by changes in absolute neutrophil count (ANC), and hematopoietic progenitor cell levels in the peripheral blood. This is a phase I open label, dose escalation study of filgrastim SD/01 in non-small cell lung cancer patients (NSCLC) and patients with other thoracic tumors treated with carboplatin and paclitaxel (Taxol).
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