IV PHO IL10 IN PATIENTS WITH STEROID REFRACTORY CROHNS

IV PHO IL10 用于类固醇难治性克罗恩病患者

• 批准号: 5218344
• 负责人: STEPHEN BRETT HANAUER
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5218344
• 关键词: Crohn's disease; biopsy; blood chemistry; clinical research; cytokine; dosage; drug adverse effect; drug screening /evaluation; gastrointestinal disorder chemotherapy; human subject; human therapy evaluation; pharmacokinetics; steroids

This is a safety, tolerance, pharmacokinetics and pharmacodynamics study of multiple doses of intravenous RHOIL-10. Data will be collected on: 1) the pharmacokinetic profile of multiple doses of intravenous RHO IL-10; 2) change in Crohn's disease activity; 3) change in cytokine levels (plasma and mucosal biopsy specimens); 4) ex vivo evaluations of steroids and IL-10 given in combination on the immune response.

这是一项安全性、耐受性、药代动力学和药效学研究