STUDY OF SELECTED LATE EFFECTS IN PATIENTS TREATED FOR NONHODGKINS LYMPHOMA

我们假设儿童时期治疗的非霍奇金氏病患者 淋巴瘤可能会增加心脏、性腺或肺部的发病率 毒性和更高的第二种恶性肿瘤的发生率 高累积剂量的某些化疗药物。身份的鉴定 毒性较小、疗效相同的化疗方案可能 帮助设计毒性较低的研究。病人们将接受 治疗指导了对这些不同器官系统的评估。本研究 是整个CCG范围内的，并基于接受过 随机分配的治疗方案。

We hypothesize that patients treated during childhood with non-Hodgkin's lymphoma may have an increased incidence of cardiac, gonadal or pulmonary toxicity and a higher incidence of second malignancies if they have had high cumulative doses of certain chemotherapies. The identification of chemotherapy regimens which have lesser toxicity with equal efficacy may help up to design less toxic studies. Patients will be undergoing therapy directed evaluations of these various organ systems. This study is CCG-wide and based on a population of patients who were treated with randomly assigned treatment regimens.