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A PHASE 1 STUDY OF TAXOL IN REFRACTORY LEUKEMIA IN CHILDREN

A PHASE 1 STUDY OF TAXOL IN REFRACTORY LEUKEMIA IN CHILDREN
紫杉醇治疗儿童难治性白血病的一期研究
批准号：
3785617
负责人：
JULIE BLATT
金额：
$0.0万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3785617
关键词：
blood chemistry clinical trials dosage drug adverse effect human subject human therapy evaluation injection /infusion leukemia neoplasm /cancer chemotherapy paclitaxel pediatric pharmacology pharmacokinetics urinalysis

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中文摘要
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英文摘要
This Phase I study attempts to look at the toxicity of Taxol in children with refractory leukemia. Patients are assigned to escalating doses of Taxol given as a continued infusion over 24 hours until the maximal tolerated dose is defined on the basis of this Childrens Cancer Group-wide study. Serial blood and urine samples are collected over a 48 hour period for pharmacokinetic determination.
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