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PHASE I STUDY OF TOPOTECAN AND CISPLATIN IN THE TREATMENT OF SOLID TUMORS

PHASE I STUDY OF TOPOTECAN AND CISPLATIN IN THE TREATMENT OF SOLID TUMORS
拓扑替康和顺铂治疗实体瘤的 I 期研究
批准号：
6246653
负责人：
JULIE BLATT
金额：
$1.91万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-12-01 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6246653
关键词：
cis platinum compound clinical research clinical trial phase I combination chemotherapy drug screening /evaluation human subject human therapy evaluation neoplasm /cancer chemotherapy pharmacokinetics thiotepa topotecan

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中文摘要
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英文摘要
Theoretical considerations based on pharmacokinetic data, studies of cisplatin and thiotepa done in adults, and recent in vitro data, suggests that the combination would be synergistic, and efficacious against pediatric cancer where individual drugs are not. The present study plan uses a standard phase I design.
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