METABOLISM OF SATURATED FATTY ACIDS OF DIFFERENT LENGTHS

不同长度饱和脂肪酸的代谢

• 批准号: 5220127
• 负责人: THOMAS A HUGHES
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5220127
• 关键词: albumins; blood lipoprotein; chylomicrons; clinical research; fatty acid metabolism; human subject; hyperlipidemia; intravenous administration; myristates; oral administration; palmitates; saturated fatty acids; stearates

To determine whether 1)myristate, palmitate, and sterate are metabolized to other fatty acids, 2)myristate, plamitate and stearate (or their metabolites) are distributed differently into the lipid components of chylomicrons, VLDL, IDL, LDL and HDL and whether they alter the composition of these lipoproteins, 3)fatty acids given IV complexed with albumin are metabolized differently than fatty acids given orally as ethyl esters, 4)patients with hyperlipidemia metabolize these fatty acids differently than subjects without hyperlipidemia.

确定1）肉豆蔻酸盐，棕榈酸盐和sterenter是否被代谢 到其他脂肪酸，2）肉豆蔻酸酯，斑点和硬脂酸盐（或它们的 代谢物的分布不同于 乳糖，VLDL，IDL，LDL和HDL以及它们是否改变 这些脂蛋白的组成，3）脂肪酸与静脉相复合 白蛋白的代谢方式与口服的脂肪酸不同，因为 乙酯，4）高脂血症的患者代谢这些脂肪酸 与没有高脂血症的受试者不同。