SYNTHESIS OF HETEROFUNCTIONALIZED HEXAARYLBENZENES

异官能团化六芳基苯的合成

• 批准号: 8168710
• 负责人: THOMAS A HUGHES
• 金额: $ 0.16万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168710
• 关键词: Binding; Computer Retrieval of Information on Scientific Projects Database; Devices; Funding; Goals; Grant; Institution; Libraries; Molecular Conformation; Nature; Nucleic Acids; Oligonucleotides; Polymers; Proteins; Reaction; Research; Research Personnel; Resources; Screening procedure; Source; Structure; System; United States National Institutes of Health; Vertebral column; combinatorial; interest; monomer; novel; polymerization; small molecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the construction of novel extended conjugated systems capable of being incorporated into useful opticoelectronic materials for such devices as heterojunction organic photovoltaics, conductive or semiconductive materials, and organic light-emitting diodes. Our synthetic approach involves easily synthesized oligomer and polymer precursors that can be reacted further to create polyaromatic networks. A phenomenon that we would like to exploit is the transfer of conformational information in the polymeric precursor- a folded structure for instance- to long-range structural order in the product material. Two examples of such systems are pictured below: a zipper polymerization of oligo(o-phenylene ethynylene) to provide long, soluble, graphitic ribbons, and a synthetic target of short buckytube-like graphitic belts. We are also interested in the construction of suitable components for self-assembling non-covalent dynamic combinatorial libraries of folding chain molecules. Nature has evolved very efficient catalytic and information-storing systems consisting of folded oligomers, namely proteins and nucleic acids. Our ultimate goal is progress towards identifying synthetic chain molecules that serve as efficient protein mimics, in their ability to fold to unique structures, to bind small molecules, and in the best-case scenario to catalyze small molecule reactions. This endeavor involves screening a large number of possible monomer backbones and chain sequences. Dynamic combinatorial libraries allow these chains to be targeted towards folding into specific conformations that are strong, specific binders of small molecules.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们有兴趣构建能够将能够纳入有用的光电材料中的新型扩展共轭系统，以用于诸如异质结，有机光伏，导电或半导体材料以及有机光发射二极管等设备。我们的合成方法涉及易于合成的低聚物和聚合物前体，这些寡聚前体可以进一步反应以创建多野型网络。我们想利用的现象是聚合物前体中构象信息的转移 - 折叠结构，以实例为实例至远程结构层。下面显示了此类系统的两个示例：寡素（O-苯基乙烯烯）的拉链聚合提供长，可溶的石墨丝带，以及一个短的BuckyTube类石墨式带的合成靶标。 我们还对构建合适的组件进行自组装的折叠链分子的非共价动态组合库的构建感兴趣。自然已经发展出非常有效的催化和信息存储系统，这些系统由折叠的低聚物，即蛋白质和核酸组成。我们的最终目标是鉴定合成链分子的进步，这些链分子可以作为有效的蛋白质模拟物，能够折叠到独特的结构，结合小分子以及在最佳案例场景中催化小分子反应的能力。这项工作涉及筛选大量可能的单体骨架和链序列。动态组合文库允许这些链的靶向折叠成特定的小分子的特定粘合剂。