SYNTHESIS OF HETEROFUNCTIONALIZED HEXAARYLBENZENES

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们对构建新型扩展共轭系统感兴趣，该系统能够并入有用的光电材料中，用于异质结有机光伏、导电或半导体材料以及有机发光二极管等器件。我们的合成方法涉及容易合成的低聚物和聚合物前体，它们可以进一步反应以形成聚芳族网络。我们想要利用的一个现象是将聚合物前体中的构象信息（例如折叠结构）转移到产品材料中的长程结构顺序。此类系统的两个示例如下图所示：低聚（邻亚苯基乙炔）的拉链聚合以提供长的、可溶的石墨带，以及短巴基管状石墨带的合成目标。 我们还对构建用于自组装折叠链分子非共价动态组合库的合适组件感兴趣。大自然已经进化出非常有效的催化和信息存储系统，由折叠寡聚物（即蛋白质和核酸）组成。我们的最终目标是在识别合成链分子方面取得进展，这些分子可作为有效的蛋白质模拟物，能够折叠成独特的结构，结合小分子，并在最好的情况下催化小分子反应。这项工作涉及筛选大量可能的单体主链和链序列。动态组合库允许这些链有针对性地折叠成特定的构象，这些构象是小分子的强特异性结合剂。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the construction of novel extended conjugated systems capable of being incorporated into useful opticoelectronic materials for such devices as heterojunction organic photovoltaics, conductive or semiconductive materials, and organic light-emitting diodes. Our synthetic approach involves easily synthesized oligomer and polymer precursors that can be reacted further to create polyaromatic networks. A phenomenon that we would like to exploit is the transfer of conformational information in the polymeric precursor- a folded structure for instance- to long-range structural order in the product material. Two examples of such systems are pictured below: a zipper polymerization of oligo(o-phenylene ethynylene) to provide long, soluble, graphitic ribbons, and a synthetic target of short buckytube-like graphitic belts. We are also interested in the construction of suitable components for self-assembling non-covalent dynamic combinatorial libraries of folding chain molecules. Nature has evolved very efficient catalytic and information-storing systems consisting of folded oligomers, namely proteins and nucleic acids. Our ultimate goal is progress towards identifying synthetic chain molecules that serve as efficient protein mimics, in their ability to fold to unique structures, to bind small molecules, and in the best-case scenario to catalyze small molecule reactions. This endeavor involves screening a large number of possible monomer backbones and chain sequences. Dynamic combinatorial libraries allow these chains to be targeted towards folding into specific conformations that are strong, specific binders of small molecules.