SYNTHESIS OF HETEROFUNCTIONALIZED HEXAARYLBENZENES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们对新型扩展共轭体系的构建感兴趣，该体系能够被用于诸如异质结有机光伏器件、导电或半导体材料以及有机发光二极管等有用的光电材料中。我们的合成方法包括容易合成的低聚物和聚合物前体，它们可以进一步反应生成多芳香族网络。我们想要利用的一个现象是，聚合物前体中的构象信息--例如折叠结构--向产品材料中的长程结构有序转移。下面是这类体系的两个例子：低聚(邻苯乙炔)的拉链聚合，以提供长的、可溶的石墨化带，以及短巴克管状石墨化带的合成靶材。 我们还对构建折叠链分子的自组装非共价动态组合文库的合适组件感兴趣。自然界已经进化出非常有效的催化和信息存储系统，由折叠的低聚物组成，即蛋白质和核酸。我们的最终目标是在识别合成链分子方面取得进展，这些分子可以作为高效的蛋白质模拟物，能够折叠成独特的结构，结合小分子，在最好的情况下可以催化小分子反应。这项工作包括筛选大量可能的单体骨架和链序列。动态组合文库允许这些链被定向折叠成特定的构象，这些构象是小分子的强大的、特定的结合体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the construction of novel extended conjugated systems capable of being incorporated into useful opticoelectronic materials for such devices as heterojunction organic photovoltaics, conductive or semiconductive materials, and organic light-emitting diodes. Our synthetic approach involves easily synthesized oligomer and polymer precursors that can be reacted further to create polyaromatic networks. A phenomenon that we would like to exploit is the transfer of conformational information in the polymeric precursor- a folded structure for instance- to long-range structural order in the product material. Two examples of such systems are pictured below: a zipper polymerization of oligo(o-phenylene ethynylene) to provide long, soluble, graphitic ribbons, and a synthetic target of short buckytube-like graphitic belts. We are also interested in the construction of suitable components for self-assembling non-covalent dynamic combinatorial libraries of folding chain molecules. Nature has evolved very efficient catalytic and information-storing systems consisting of folded oligomers, namely proteins and nucleic acids. Our ultimate goal is progress towards identifying synthetic chain molecules that serve as efficient protein mimics, in their ability to fold to unique structures, to bind small molecules, and in the best-case scenario to catalyze small molecule reactions. This endeavor involves screening a large number of possible monomer backbones and chain sequences. Dynamic combinatorial libraries allow these chains to be targeted towards folding into specific conformations that are strong, specific binders of small molecules.