MECHANISMS UNDERLYING ABNORMAL AMBULATORY BLOOD PRESSURE PATTERNS

异常动态血压模式的潜在机制

• 批准号: 5220129
• 负责人: GREGORY ALAN HARSHFIELD
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5220129
• 关键词: adrenocorticotropic hormone; angiotensin /renin /aldosterone hypertension; bioperiodicity; blood pressure; clinical research; dietary sodium; disease /disorder proneness /risk; hemodynamics; hormone regulation /control mechanism; human subject; kidney circulation; nutrition related tag; renal tubular transport

We plan to 1)identify subjects at risk for the development of HTN, 2)determine the influence of risk, status (HR vs NR) or ABP patterns on a normal Na+ diet and determine the influence of risk status on 24-hour hormonal patterns (PRA, PAC<ACTH) on a normal Na+ diet, 3)determine the influence of risk status on pattern of renal hemodynamics and proximal tubular reabsorption and compare the groups with regard to the relationship among the hormonal activity.

我们计划：1）识别有HTN发展风险的受试者， 2)确定风险、状态（HR vs NR）或ABP模式对 正常的Na+饮食，并确定风险状态对24小时 激素模式（PRA，PAC<ACTH）正常钠+饮食，3）确定 高危状态对肾血流动力学及近端血流影响 肾小管重吸收，并比较各组在 与荷尔蒙活动之间的关系。