UK Dementias Platform

英国痴呆症平台

• 批准号: MR/L023784/1
• 负责人: John Gallacher
• 金额: $ 1675.43万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL023784%2F1
• 关键词: UK; Dementias; Platform

The UK Dementias Platform (UKDP) is a radically new approach to dementias research, bringing together data from around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of slowing it down. The platform has been funded to the level of £4.5M and invited to apply for a further £7.5M. To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies. We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself. There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.

英国痴呆症平台（UKDP）是一种全新的痴呆症研究方法，汇集了来自22个队列的约2，000，000名研究参与者的数据，试图发现痴呆症的原因，并找出减缓痴呆症的方法。该平台已获得450万英镑的资金，并被邀请申请进一步的750万英镑。为了实现我们发现痴呆症的原因并找到减缓痴呆症的方法的目标，我们将分析数十年来从英国各地收集的数据，以确定药物研究的目标。我们还将丰富战略选择的队列，为痴呆症的研究提供资源。这将涉及到发现早期痴呆症过程是如何开始的，我们的基因如何影响我们患痴呆症的风险，以及我们的身体在维护和修复自身方面出了什么问题。这项工作涉及许多实际挑战，包括知道如何在大型研究中评估痴呆症，在大型研究中，让每个人都接受医生检查将是非常昂贵的。另一个挑战是如何测量人群中的认知能力下降，因为当人们开始下降时，他们通常不太愿意做认知测试。围绕这项工作还有重要的伦理问题，我们有具体的项目，研究参与详细测量研究以及考虑大脑捐赠的伦理法律的和社会问题。为了尽快产生影响，我们将与最有能力将基本科学知识转化为有效疗法的行业伙伴密切合作。即使我们不能在短期内治愈痴呆症，如果我们找到减缓痴呆症的方法，使没有人在年老时失去尊严，也将是一个成功。

项目成果

Creating A Research Ready Data Asset and Empowering Dynamic and Efficient Research: The Sail Dementia E-Cohort (SDEC)

创建研究就绪数据资产并支持动态和高效的研究：Sail 痴呆症电子队列 (SDEC)

• DOI: 10.23889/ijpds.v5i5.1518
• 发表时间: 2020
• 期刊: International Journal of Population Data Science
• 作者: Akbari A

Viscosity and fragility of confined polymer nanocomposites: a tale of two interfaces.

• DOI: 10.1039/c8nr10362c
• 发表时间: 2019-04
• 期刊: Nanoscale
• 影响因子: 6.7
• 作者: Nimmi Das A;N. Begam;Mohd Ibrahim;S. Chandran;Venkat Padmanabhan;M. Sprung;J. Basu

Mirtazapine's effect on the QT interval in medically hospitalized patients.

• DOI: 10.9740/mhc.2020.01.030
• 发表时间: 2020-01-01
• 期刊: The mental health clinician
• 作者: Allen, Nicholas D;Leung, Jonathan G;Palmer, Brian A
• 通讯作者: Palmer, Brian A

Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort.

• DOI: 10.1016/j.jad.2016.06.049
• 发表时间: 2016-11-01
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Allan CL;Sexton CE;Filippini N;Topiwala A;Mahmood A;Zsoldos E;Singh-Manoux A;Shipley MJ;Kivimaki M;Mackay CE;Ebmeier KP
• 通讯作者: Ebmeier KP

Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder.

• DOI: 10.1001/jamapsychiatry.2017.3485
• 发表时间: 2018-01-01
• 期刊: JAMA psychiatry
• 影响因子: 25.8
• 作者: Allardyce J;Leonenko G;Hamshere M;Pardiñas AF;Forty L;Knott S;Gordon-Smith K;Porteous DJ;Haywood C;Di Florio A;Jones L;McIntosh AM;Owen MJ;Holmans P;Walters JTR;Craddock N;Jones I;O'Donovan MC;Escott-Price V
• 通讯作者: Escott-Price V