STRESS DETERMENANTS OF LOW BIRTH WEIGHT AND PRETERM BIRTH

低出生体重和早产的压力决定因素

• 批准号: 5220472
• 负责人: CALVIN J HOBEL
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5220472
• 关键词: anxiety; biochemistry; biophysics; body physical activity; catecholamines; clinical research; disease /disorder proneness /risk; gestational age; human subject; low birth weight infant human; newborn human (0-6 weeks); postpartum; premature infant human; premature labor; prenatal stress; psychological stressor; psychophysics; restraint; urinalysis

This investigation is designed to differentiate between the contributions of prenatal psychological stress and physical strain or exertion on low birth weight and preterm births. Our preliminary studies have demonstrated that higher levels of urinary catecholamines are detected in patients with higher mental stress scores and that physical activity appears to reverse these changes. Over the next three years 670 women will be assessed at 3 intervals in pregnancy and 4-6 weeks postpartum, and data collected about prenatal risk, anxiety, biochemical and biophysical indicators of stress, labor, delivery and neonatal outcome.

该调查旨在区分贡献 产前心理压力，身体应变或低劳动 出生体重和早产。我们的初步研究 证明检测到较高水平的尿液儿茶酚胺 在精神压力评分较高的患者中，体育活动 似乎扭转了这些变化。 在接下来的三年中，有670名女性 将在怀孕和产后4-6周以3个间隔进行评估， 以及收集有关产前风险，焦虑，生化和的数据 压力，劳动，分娩和新生儿结局的生物物理指标。