STRESS DETERMENANTS OF LOW BIRTH WEIGHT AND PRETERM BIRTH

低出生体重和早产的压力决定因素

• 批准号: 5220472
• 负责人: CALVIN J HOBEL
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5220472
• 关键词: anxiety; biochemistry; biophysics; body physical activity; catecholamines; clinical research; disease /disorder proneness /risk; gestational age; human subject; low birth weight infant human; newborn human (0-6 weeks); postpartum; premature infant human; premature labor; prenatal stress; psychological stressor; psychophysics; restraint; urinalysis

This investigation is designed to differentiate between the contributions of prenatal psychological stress and physical strain or exertion on low birth weight and preterm births. Our preliminary studies have demonstrated that higher levels of urinary catecholamines are detected in patients with higher mental stress scores and that physical activity appears to reverse these changes. Over the next three years 670 women will be assessed at 3 intervals in pregnancy and 4-6 weeks postpartum, and data collected about prenatal risk, anxiety, biochemical and biophysical indicators of stress, labor, delivery and neonatal outcome.

这项调查旨在区分贡献 产前心理压力和身体紧张或劳累程度低 出生体重和早产。我们的初步研究有 证明尿液中儿茶酚胺的含量较高 精神压力评分较高且体力活动较多的患者 似乎扭转了这些变化。 未来三年 670 名女性 将在怀孕期间和产后 4-6 周内每隔 3 次进行评估， 以及收集的有关产前风险、焦虑、生化和 压力、分娩、分娩和新生儿结局的生物物理指标。