ACUTE INTERACTION OF THEOPHYLLINE AND SDZ WAG 994

该研究是一项双盲、随机、安慰剂对照的临床研究， 试验采用2X2析因设计。 目的是评估 抗氧化剂维生素E和C对脂质过氧化作用的影响。 这项研究是 在约翰霍普金斯的门诊综合研究中心进行 医院和健康诊所在西巴尔的摩。 研究人群 将由180名20岁或以上的健康成年人组成。 受试者参加一次筛选访视、一次随机化访视和两次 后续补充。 参与者被随机分为四组 干预组：（1）单独补充维生素E，400 IU/d，（2） 单独补充维生素C，500 mg/d，（3）联合维生素E（400 IU/d）和维生素C（500 mg/d）补充剂，以及（4）安慰剂 治疗 结局指标（F2-异前列烷和丙二醛）和 中间终点（总氧自由基吸收能力，脂质 图和血清维生素C和E水平） 样品将在实验室进行。

The study is a double-masked, randomized, placebo-controlled clinical trial with a 2X2 factorial design. The goal is to assess the efficacy of antioxidant vitamins E and C on lipid peroxidation. The study is conducted at the Outpatient General Research Center in the Johns Hopkins Hospital and the Pro-Health Clinic in West Baltimore. Study population will consist of 180 healthy adults, aged 20 years or older. Participants attend a screening visit, a randomization visit and two follow-up supplements. Participants are randomized into one of four intervention groups: (1) vitamin E supplementation alone, 400 IU/d, (2) vitamin C supplementation alone, 500 mg/d, (3) combined vitamin E (400 IU/d) and vitamin C (500 mg/d) supplementation, and (4) placebo treatment. Outcome measures (F2-isoprostane and malondialdehyde) and intermediate endpoints (total oxygen-radical absorbance capacity, lipid profiles, and serum levels of vitamin C and E) from urine and blood samples will be done in laboratories.